NUT midline lung cancer: a rare case report with literature review

Gupta, Ruby; Mumaw, Derek; Antonios, Bana; Anusim, Nwabundo; Dhulipalla, Sharmila P.; Stender, Michael; Huben, Marianne Terese; Jaiyesimi, Ishmael

doi:10.21037/acr-21-35

Cited by 8 publications

(11 citation statements)

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“…This study evaluated 55 patients (36 men and 19 women) among the 35 articles [ 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ] with a mean age of 41.4 years (range, 6–82). The male to female ratio was approximately 1.89 to 1.…”

Section: Resultsmentioning

confidence: 99%

Diagnosis, Treatment and Prognosis of Primary Pulmonary NUT Carcinoma: A Literature Review

Yuan

Guo

2022

Current Oncology

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NUT carcinoma is a rare, highly lethal cancer characterized with the rearrangement of the nuclear protein in testis (NUT) gene on chromosome 15q14, which primarily occurs in the midline organs. Primary pulmonary NUT carcinoma (NC) lacks characteristic clinical manifestations, which leads to the high rate of misdiagnose and nonstandard treatment. To date, fewer than one hundred cases have been reported worldwide. Here, a comprehensive literature search involving a total of 35 articles with 55 patients was conducted in this paper. We reviewed and analyzed the associated clinical and pathological characteristics, the efficacy of various treatment options and the prognosis. Pulmonary NC mainly occurred in middle young-aged men (median age, 36) with no smoking history (2:1) and would present with symptoms of cough (63.6%), dyspnea (29.5%), chest pain (18.2%) and hemoptysis (18.2%). The initial imaging frequently revealed large and irregular lesions in the lower lobe (46.5%) of the left or right lungs; lymph node metastasis was also prevalent (91.9%). A focal squamous differentiation with abrupt keratinization often occurred in the undifferentiated or poorly differentiated (93.75%) tumor cells, with abundant necrosis and numerous neutrophils infiltrated. The mean overall survival (OS) in patients of this malignant disease was 6.21 months, and the median OS was 4.4 months. According to our results, this disease is sensitive to radiotherapy, and chemoradiotherapy (either concurrent chemoradiotherapy or sequential chemoradiotherapy) was the most efficient therapeutic regimen to prolong the OS of patients with pulmonary NC.

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Section: Resultsmentioning

confidence: 99%

Diagnosis, Treatment and Prognosis of Primary Pulmonary NUT Carcinoma: A Literature Review

Yuan

Guo

2022

Current Oncology

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“…We searched the literature in the PubMed and Google Scholar databases using the keywords containing lung, NUT and PET. The PET/CT manifestations of total 18 cases from 2014 to 2022 are summarized in Table 3 (12,22,(24)(25)(26)(27)(28)(29). The most frequently involved lobe is right upper lobe of the lung among these cases (8 in 17) and the mean max diameter of the lung lesions is 5.0 cm (1.4-12.0 cm).…”

Section: Discussionmentioning

confidence: 99%

Clinical imaging of primary pulmonary nucleoprotein of the testis carcinoma

Huang

Zhang²,

Yang³

et al. 2023

Front. Med.

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ObjectivePrimary pulmonary nucleoprotein of the testis (NUT) carcinoma is very rare in the clinic. In this study, the clinicopathological manifestations and imaging features of the primary pulmonary NUT carcinoma were investigated to improve the diagnosis of this disease.MethodsSix patients with pathologically diagnosed pulmonary NUT carcinoma were analyzed, including three males and three females, aged 19–64 (49.00 ± 16.40) years, with clinical manifestations of cough in two cases, hoarseness in one case, blood in sputum in one case, chest pain in one case, and physical examination findings in one case, with a disease duration of 5 days to 4 months. The clinical and imaging data including CT and PET/CT were retrospectively analyzed. Further literature reviews were analyzed in both pulmonary and extrapulmonary NUT carcinoma cases who performed 18F-FDG PET/CT.ResultsMost of the patients with pulmonary NUT carcinomas presented as heterogeneous lobulated masses (83.33%), four cases (66.67%) were located in the upper lobe of the left lung, one case (16.67%) in the middle lobe of the right lung, and one case (16.67%) in the lower lobe of the right lung, with the maximum diameter ranging from 1.30 to 8.90 cm and the median of 3.55 cm, most of them were irregularly shaped, with more lobulated margins and more heterogeneous density (83.33%), and the enhancement was mild. PET/CT showed increased 18F-FDG uptake in the lesion and metastatic areas. Both the pulmonary NUT patients in this study and literature reviews showed the SUVmax of the tumor ranged from 5 to 40 with an average value of 12.8, whereas that of extrapulmonary lesions had a range of SUVmax at 4.5–64.1 and a mean of 13.8.ConclusionIn patients with central lung masses, rapid disease progression, and poor response to initial treatment, the possibility of NUT cancer should be considered and anti-NUT monoclonal antibody immunohistochemical staining, combined with genetic detection, if necessary, should be performed as soon as possible. CT and PET/CT imaging are essential for the staging, management, treatment response assessment, and monitoring of pulmonary NUT cancer.

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“…Out of the 20 patients with pulmonary NUT carcinoma, 17 were with a detailed clinical history, where the main clinical manifestations included cough (76%), while other symptoms include wheezing (35%), chest tightness (35%), dyspnea (35%), chest pain (35%), shoulder pain (35%), low back pain (35%), hemoptysis or sputum with blood (29%), fever (18%). Table 1 [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] shows 23 pulmonary NUT carcinoma cases, 15 men and 8 women whose age at diagnosis was 7 - 74 years, the average age was 37 years, and the median age was 30 years. The clinical manifestations of pulmonary NC in these 23 patients were similar to those reported by HE et al ., and the most important clinical manifestation was cough.…”

Section: Clinical Characteristicsmentioning

confidence: 99%

Nuclear protein in testis carcinoma of the lung

Chen

2023

Translational Oncology

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NUT midline lung cancer: a rare case report with literature review

Cited by 8 publications

References 0 publications

Diagnosis, Treatment and Prognosis of Primary Pulmonary NUT Carcinoma: A Literature Review

Diagnosis, Treatment and Prognosis of Primary Pulmonary NUT Carcinoma: A Literature Review

Clinical imaging of primary pulmonary nucleoprotein of the testis carcinoma

Nuclear protein in testis carcinoma of the lung

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