NUT midline carcinoma in a young pregnant female: a case report

Abstract

Introduction The NUT midline carcinoma is a rare tumor mostly reported in the midline of upper aerodigestive tract and mediastinum. Children as well as adolescents are affected without a gender distribution. A standard treatment is not established. So far, there exists no reported case of a pregnant female suffering from NUT midline carcinoma with musculoskeletal manifestation. Case presentation A 34-year-old woman was referred to our outpatient clinic by the general practitioner during her 31st week of pregnancy suffering from shoulder pain and dyspnea. So far, dyspnea was interpreted as a typical pregnancy-related symptom. However, a chest X-ray showed a tumor mass in the right lung in close relation to the scapula. Further examinations found metastases in different areas of the body. No pregnancy-related complications were detected by obstetric examination. After an interdisciplinary perinatal case discussion, cesarean section was directly followed by an open biopsy of the right side scapula tumor lesion. A NUT midline carcinoma was diagnosed by immunohistochemistry. Due to disseminated tumor disease in multiple non-resectable locations, a palliative systemical chemotherapy was started by the oncological outpatient clinic. Conclusion This report presents the case of the very rare NUT midline carcinoma under pregnancy which made interdisciplinary case discussions indispensable for therapy planning.

Immunotherapy and Targeting the Tumor Microenvironment: Current Place and New Insights in Primary Pulmonary NUT Carcinoma

“…For patients receiving chemotherapy, after a short-term response or stable disease, they often progressed rapidly ( 13 , 57 ). According to the literatures, the longest PFS was 5 months ( 74 ) and the longest OS was 13 months ( 75 ). However, until now, no chemotherapy regimen with definite therapeutic effect has been recognized.…”

Nuclear protein of the testis midline carcinoma of the thorax

“…The International NMC registry only included data from 1993 to 2007, and because our investigation of NMC of the thorax included cases reported between 2006 and 2021, some cases may have overlapped. Our literature search identified 28 articles describing the clinical features of NMC ( 11–38 ). After reviewing these articles describing the clinical features of NMC, we decided to describe 11 clinical features (chief complaint, sex, age at diagnosis, smoking history, primary site, presence or absence of distant metastasis at the time of initial diagnosis, treatment (chemotherapy, RT, surgery), survival after diagnosis and type of genetic mutation).…”