Nursing interventions in depressed children with low serum levels of BDNF

Sun, Qing-Rong; Cui, Chuanying; Fu, Yanhong; Ma, Siyu

doi:10.3892/etm.2017.4921

Cited by 8 publications

(7 citation statements)

References 20 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This suggests that reduced BDNF may be associated with the diagnosis of depressive disorder. Sun et al observed lower BDNF levels in patients with depressive disorder [64]. In this study, the group receiving comprehensive treatment showed higher serum BDNF levels than the group receiving routine treatment.…”

Section: The Cytokines In Neuroinflammationsupporting

confidence: 50%

See 1 more Smart Citation

Molecular Biomarkers for Pediatric Depressive Disorders: A Narrative Review

Lee¹,

Chi²,

Lee³

2021

Preprint

View full text Add to dashboard Cite

Depressive disorder in childhood and adolescence is a highly prevalent mood disorder that tends to recur throughout life. Untreated mood disorders can adversely impact a patient's quality of life and cause socioeconomic loss. Thus, an accurate diagnosis and appropriate treatment is crucial. However, until now, diagnoses and treatments are conducted according to clinical symptoms. Objective and biological validation are lacking. This may result in a poor outcome for patients with depressive disorder. Research has been conducted to identify the biomarkers that are related to depressive disorder. Cumulative evidence has revealed that certain immunologic biomarkers in-cluding brain-derived neurotrophic factor (BDNF) and cytokines, gastrointestinal biomarkers, hormones, oxidative stress, and certain hypothalamus-pituitary axis biomarkers are associated with depressive disorder. This article reviews the biomarkers related to the diagnosis and treatment of pediatric depressive disorders. To date, clinical biomarker tests are not yet available for diagnosis or for the prediction of treatment prognosis. However, cytokines such as Interleukin-2, interfer-on-gamma, tumor necrosis factor-alpha, and BDNF have shown significant results in previous studies of pediatric depressive disorder. These biomarkers have the potential to be used for diagnosis, prognostic assessment, and group screening for those at high risk.

show abstract

Section: The Cytokines In Neuroinflammationsupporting

confidence: 50%

“…The results of these changes in BDNF were relatively consistent in adults with MDD. However, in children and adolescents, the results were inconsistent [50][51][52]64].…”

Section: The Cytokines In Neuroinflammationmentioning

confidence: 98%

Molecular Biomarkers for Pediatric Depressive Disorders: A Narrative Review

Lee¹,

Chi²,

Lee³

2021

Preprint

View full text Add to dashboard Cite

show abstract

“…22 This scale has been used in some adolescent studies. 23–25 A Chinese version of the scale suitable for teenagers was used in this study. 26…”

Section: Methodsmentioning

confidence: 99%

Clinical characteristics of moderate–severe obsessive–compulsive disorder in children and adolescents in China

et al. 2020

View full text Add to dashboard Cite

Objective This study reports clinical characteristic of moderate–severe obsessive–compulsive disorder (OCD) among school students in China. Methods We examined 153 patients for the distribution of OCD symptoms using the Yale-Brown Obsessive Compulsive Scale Symptoms Checklist, the severity of anxiety and depression symptoms using the Hamilton Anxiety Scale and the Hamilton Depression Scale-24, respectively, and impairment in learning, family and social functions using the Pediatric Quality of Life Enjoyment and Satisfaction Questionnaire. Results The number of total OCD, obsession and compulsion symptoms was 6.71 (standard deviation [SD] = 2.25), 3.77 (SD = 1.32) and 2.94 (SD = 1.59), respectively. The incidence of moderate and severe depressive symptoms for junior high school students was significantly higher than for primary and high school students. The number of children and adolescents with OCD increased with age, reaching a peak in the senior high school stage. Conclusion The most common symptoms in children and adolescent OCD patients are miscellaneous obsessions, aggressiveness, religiousness, checking, miscellaneous compulsions, cleaning-washing and repeating. These patients show a relatively high co-occurrence rate of anxiety symptoms and depressive symptoms, which impairs their learning, as well as their family and social functions.

show abstract

“…The results of these changes in BDNF levels were relatively consistent in adults with MDD. However, in children and adolescents, the results were inconsistent [ 55 , 56 , 57 , 69 ]. Table 2 shows a summary of the previous studies of BDNF in pediatric depressive disorder.…”

Section: Neuroimmune System and Pediatric Depressive Disordermentioning

confidence: 99%

“…This suggests that reduced BDNF levels may be associated with the diagnosis of depressive disorder. Sun et al observed lower BDNF levels in patients with depressive disorder [ 69 ]. In this study, the group receiving comprehensive treatment showed higher serum BDNF levels than the group receiving routine treatment.…”

Section: Neuroimmune System and Pediatric Depressive Disordermentioning

confidence: 99%

Molecular Biomarkers for Pediatric Depressive Disorders: A Narrative Review

Lee

Chi

Lee

2021

IJMS

View full text Add to dashboard Cite

Depressive disorder in childhood and adolescence is a highly prevalent mood disorder that tends to recur throughout life. Untreated mood disorders can adversely impact a patient’s quality of life and cause socioeconomic loss. Thus, an accurate diagnosis and appropriate treatment is crucial. However, until now, diagnoses and treatments were conducted according to clinical symptoms. Objective and biological validation is lacking. This may result in a poor outcome for patients with depressive disorder. Research has been conducted to identify the biomarkers that are related to depressive disorder. Cumulative evidence has revealed that certain immunologic biomarkers including brain-derived neurotrophic factor (BDNF) and cytokines, gastrointestinal biomarkers, hormones, oxidative stress, and certain hypothalamus-pituitary axis biomarkers are associated with depressive disorder. This article reviews the biomarkers related to the diagnosis and treatment of pediatric depressive disorders. To date, clinical biomarker tests are not yet available for diagnosis or for the prediction of treatment prognosis. However, cytokines such as Interleukin-2, interferon-gamma, tumor necrosis factor-alpha, and BDNF have shown significant results in previous studies of pediatric depressive disorder. These biomarkers have the potential to be used for diagnosis, prognostic assessment, and group screening for those at high risk.

show abstract

Nursing interventions in depressed children with low serum levels of BDNF

Cited by 8 publications

References 20 publications

Molecular Biomarkers for Pediatric Depressive Disorders: A Narrative Review

Molecular Biomarkers for Pediatric Depressive Disorders: A Narrative Review

Clinical characteristics of moderate–severe obsessive–compulsive disorder in children and adolescents in China

Molecular Biomarkers for Pediatric Depressive Disorders: A Narrative Review

Contact Info

Product

Resources

About