Abstract:High-dose, continuous-infusion interleukin-2 (IL-2) followed by pulse dose and concurrent administration of famotidine has demonstrated response rates of 64% and 33% in patients with metastatic melanoma and metastatic renal cell carcinoma, respectively. Currently, no information is available concerning the nursing care of patients receiving that IL-2 regimen. Given the high response rates of patients on the treatment, attention by the nursing profession is warranted. Effective nursing care of patients receivin… Show more
“…There are also a number of treatment-related adverse events that it is important for patients with RCC and HCC treatments to be aware of so that they can be empowered to monitor and manage any emergent events. If these are not anticipated by patients, or are poorly managed by their doctors and carers, they can contribute to drug discontinuation, reduced QoL and suboptimal outcomes (Brunot et al, 2018;Tyre and Quan, 2007). The role of nurses in AE management and the implications for treatment adherence have been recognized in both RCC and HCC (Bourdeanu et al, 2011;Gish et al, 2012).…”
Section: Symptom and Adverse Event Monitoring And Managementmentioning
confidence: 99%
“…The role of nurses in AE management and the implications for treatment adherence have been recognized in both RCC and HCC (Bourdeanu et al, 2011;Gish et al, 2012). Anticipation, recognition, and timely and appropriate management of AEs (including specialist referral if necessary) have the potential to improve patient outcomes (Ciccolini et al, 2017;Hull and Armstrong, 2010;Tyre and Quan, 2007;Walko and Grande, 2014).…”
Section: Symptom and Adverse Event Monitoring And Managementmentioning
confidence: 99%
“…Nurses can assess patients' (and caregivers') understanding of potential treatment-related AEs and reaffirm the importance of tracking and reporting them (Hull and Armstrong, 2010;Moldawer and Figlin, 2008). Providing patients with an information sheet at discharge may be useful in this context (Tyre and Quan, 2007).…”
Section: Symptom and Adverse Event Monitoring And Managementmentioning
confidence: 99%
“…The range of potential treatment-related AEs and the rapidly evolving therapeutic landscapes for HCC and RCC can make optimal AE management challenging. Oncology nurses must keep up to date with the latest advances in the field, including the pathophysiology, incidence, assessment and clinical presentation of AEs (Bourdeanu et al, 2011;Ciccolini et al, 2017;Esper, 2012;Moldawer and Figlin, 2008;Moldawer and Wood, 2020;Tyre and Quan, 2007). Various papers have been published on nurse-led management of AEs with RCC and HCC treatments; these include recommendations from a European nursing task group on managing the side effects of targeted therapies (Edmonds et al, 2012), and the management of dermatologic side effects of immunotherapies for advanced RCC (Ciccolini et al, 2017).…”
Section: Symptom and Adverse Event Monitoring And Managementmentioning
confidence: 99%
“…Various papers have been published on nurse-led management of AEs with RCC and HCC treatments; these include recommendations from a European nursing task group on managing the side effects of targeted therapies (Edmonds et al, 2012), and the management of dermatologic side effects of immunotherapies for advanced RCC (Ciccolini et al, 2017). They also include specific papers on the use of sorafenib for advanced RCC and HCC (Hull and Armstrong, 2010;Walko and Grande, 2014), pazopanib for metastatic RCC (Bourdeanu et al, 2011) and high-dose interleukin-2 therapy for RCC (Tyre and Quan, 2007;Yost et al, 2010). Resolution of some difficult-to-manage AEs (e.g.…”
Section: Symptom and Adverse Event Monitoring And Managementmentioning
This systematic literature review identified publications evaluating the role and benefits of nurse-led care in the management of patients with a diagnosis of renal cell carcinoma (RCC) or hepatocellular carcinoma (HCC). Methods: The review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidance. Structured searches of the PubMed database and the EMCare nursing and allied health database were conducted (August 11, 2021). Eligible publications were English-language, full-text, peer-reviewed journal articles featuring HCC and/or RCC populations, interventions involving nurses, any/no comparators, and reporting any related healthcare outcomes. Data on study design and size, patient characteristics and impact of nursing care were extracted. Results: Fifty-six relevant articles were identified (43 on HCC; 10 on RCC; 3 on HCC and RCC). The literature described the role and impact of oncology nurses across a variety of care functions, including in health promotion and screening, care coordination, holistic oversight, symptom and adverse event monitoring and management, and emotional support. Twenty-nine empirical studies/case reports were identified demonstrating benefit of nurse-led interventions in HCC/liver cancer (n = 28) and RCC (n = 1). Benefits were achieved through: improved patient participation in screening programs; reduced time to diagnosis; improved treatment adherence, reduced treatment complications, dose reductions and outpatient visits, and potential cost savings. Conclusions: The oncology nurse plays a multifaceted role in the care of patients with HCC and RCC, but more evidence from nurse-led interventions is required to guide optimal multidisciplinary care of patients with these conditions.
“…There are also a number of treatment-related adverse events that it is important for patients with RCC and HCC treatments to be aware of so that they can be empowered to monitor and manage any emergent events. If these are not anticipated by patients, or are poorly managed by their doctors and carers, they can contribute to drug discontinuation, reduced QoL and suboptimal outcomes (Brunot et al, 2018;Tyre and Quan, 2007). The role of nurses in AE management and the implications for treatment adherence have been recognized in both RCC and HCC (Bourdeanu et al, 2011;Gish et al, 2012).…”
Section: Symptom and Adverse Event Monitoring And Managementmentioning
confidence: 99%
“…The role of nurses in AE management and the implications for treatment adherence have been recognized in both RCC and HCC (Bourdeanu et al, 2011;Gish et al, 2012). Anticipation, recognition, and timely and appropriate management of AEs (including specialist referral if necessary) have the potential to improve patient outcomes (Ciccolini et al, 2017;Hull and Armstrong, 2010;Tyre and Quan, 2007;Walko and Grande, 2014).…”
Section: Symptom and Adverse Event Monitoring And Managementmentioning
confidence: 99%
“…Nurses can assess patients' (and caregivers') understanding of potential treatment-related AEs and reaffirm the importance of tracking and reporting them (Hull and Armstrong, 2010;Moldawer and Figlin, 2008). Providing patients with an information sheet at discharge may be useful in this context (Tyre and Quan, 2007).…”
Section: Symptom and Adverse Event Monitoring And Managementmentioning
confidence: 99%
“…The range of potential treatment-related AEs and the rapidly evolving therapeutic landscapes for HCC and RCC can make optimal AE management challenging. Oncology nurses must keep up to date with the latest advances in the field, including the pathophysiology, incidence, assessment and clinical presentation of AEs (Bourdeanu et al, 2011;Ciccolini et al, 2017;Esper, 2012;Moldawer and Figlin, 2008;Moldawer and Wood, 2020;Tyre and Quan, 2007). Various papers have been published on nurse-led management of AEs with RCC and HCC treatments; these include recommendations from a European nursing task group on managing the side effects of targeted therapies (Edmonds et al, 2012), and the management of dermatologic side effects of immunotherapies for advanced RCC (Ciccolini et al, 2017).…”
Section: Symptom and Adverse Event Monitoring And Managementmentioning
confidence: 99%
“…Various papers have been published on nurse-led management of AEs with RCC and HCC treatments; these include recommendations from a European nursing task group on managing the side effects of targeted therapies (Edmonds et al, 2012), and the management of dermatologic side effects of immunotherapies for advanced RCC (Ciccolini et al, 2017). They also include specific papers on the use of sorafenib for advanced RCC and HCC (Hull and Armstrong, 2010;Walko and Grande, 2014), pazopanib for metastatic RCC (Bourdeanu et al, 2011) and high-dose interleukin-2 therapy for RCC (Tyre and Quan, 2007;Yost et al, 2010). Resolution of some difficult-to-manage AEs (e.g.…”
Section: Symptom and Adverse Event Monitoring And Managementmentioning
This systematic literature review identified publications evaluating the role and benefits of nurse-led care in the management of patients with a diagnosis of renal cell carcinoma (RCC) or hepatocellular carcinoma (HCC). Methods: The review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidance. Structured searches of the PubMed database and the EMCare nursing and allied health database were conducted (August 11, 2021). Eligible publications were English-language, full-text, peer-reviewed journal articles featuring HCC and/or RCC populations, interventions involving nurses, any/no comparators, and reporting any related healthcare outcomes. Data on study design and size, patient characteristics and impact of nursing care were extracted. Results: Fifty-six relevant articles were identified (43 on HCC; 10 on RCC; 3 on HCC and RCC). The literature described the role and impact of oncology nurses across a variety of care functions, including in health promotion and screening, care coordination, holistic oversight, symptom and adverse event monitoring and management, and emotional support. Twenty-nine empirical studies/case reports were identified demonstrating benefit of nurse-led interventions in HCC/liver cancer (n = 28) and RCC (n = 1). Benefits were achieved through: improved patient participation in screening programs; reduced time to diagnosis; improved treatment adherence, reduced treatment complications, dose reductions and outpatient visits, and potential cost savings. Conclusions: The oncology nurse plays a multifaceted role in the care of patients with HCC and RCC, but more evidence from nurse-led interventions is required to guide optimal multidisciplinary care of patients with these conditions.
Introduction
A discussion about sexuality should become a routine part of the personalized care pathway for patients with cancer.
Aim
To assess rates of patient discussion about sexuality with health care providers after cancer.
Methods
We used data from the representative French nationwide 2012 VICAN survey, which included 4,349 adults 18 to 82 years old who were still alive 2 years after diagnosis at 12 cancer sites.
Main Outcome Measures
Self-reported rates of discussion about sexuality with health care providers were assessed, and associated factors were tested after systematic adjustment for a sexual health indicator (created from six items of the Relationship and Sexuality Scale).
Results
Of 4,181 respondents to the question on a discussion about sexuality, 54.7% reported that nobody had proposed a discussion to them, 21.9% did not want any discussion, and 23.4% had had a discussion. Women had less discussion about sexuality with health care providers (11.1% vs 36.7% of men, P < .001) and were more likely to request a discussion at their own initiative (62.9% vs 48.0% of men, P < .001). Discussion about sexuality was more frequent with patients with prostate (56.3%) and cervical (39.6%) cancer, but increasing age was associated with a greater reluctance to discuss this issue (odds ratio = 1.17, 95% CI = 1.04–1.2). The likelihood of discussion increased with severe sexual problems, radiotherapy, general sequelae, having an information-seeker profile, previous professional psychological help, and initial treatment in private centers. Patients initially wishing for psychological help were more likely to desire a discussion about sexuality.
Conclusion
Sexuality receives little attention in French patients with cancer. Inequalities in the discussion about sexuality were observed in relation to the type of care center where the patient was initially managed. Information on supportive interventions, including more systematic referral for professional psychological help, should be developed to facilitate discussion and should be offered to all patients, irrespective of severity of sexual problems, age, sex, cancer site, and care center.
As the use of immunotherapeutic agents increases in single-agent and multimodality treatment regimens, oncology nurses face the challenge of administering and caring for patients receiving new and unique agents. Oncology Nursing Society clinical staff and clinical nurses collaborated to produce a set of recommendations to educate nurses involved with the monitoring of patients receiving immunotherapy on administration procedures and safe handling of these agents to ensure patient and staff safety and to reduce risk of error. The recommendations are meant to provide clinical nurses with a framework on which to build policies and procedures for administering new treatment modalities. .
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