Nursing behavior in rats is impaired in a small nestbox and with hyperthermic pups

Stern, Judith M.; Lonstein, Joseph S.

doi:10.1002/(sici)1098-2302(199603)29:2<101::aid-dev2>3.0.co;2-w

Cited by 47 publications

(19 citation statements)

References 49 publications

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“…The deprivation period remained at 12 h/d for the next Y days (P8 to P17). During deprivation, pups remained in a heated cage, with body temperature maintained at approximately 34°C (23). After the deprivation period, the pups were housed with their respective dams.…”

Section: Malnutrition Paradigmmentioning

confidence: 99%

Malnutrition Increases Dentate Granule Cell Proliferation in Immature Rats After Status Epilepticus

et al. 2000

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Summary:Purpose: Nutritional insults early in life have a profound and often permanent effect on the development of the central nervous system. A direct relationship between malnutrition and epilepsy has not been established; however, it is believed that inadequate nutrition may predispose the brain to seizures. This study was designed to determine whether neonatally malnourished rats are different from nourished rats in terms of flurothyl seizure susceptibility at postnatal day (P)15, in the behavioral manifestations of seizures, and in status epilepticus-induced hippocampal injury.Methods: Sprague-Dawley rat pups were maintained on a starvation regimen from P2 until P17. Age-matched control rats were not exposed to starvation. At P15, all animals were exposed to flurothyl-induced status epilepticus. At P17, the rats received a single injection of bromodeoxyuridine (50 mg/kg intraperitoneal) to determine the extent of genesis of new cells in the dentate gyrus. At P18, the rats were killed, and the brains were processed for histology and immunohistochemistry.Results: Preliminary analysis indicates that early malnutrition did not modify flurothyl seizure susceptibility or the behavioral manifestations of seizures at P15. Histological assessment did not reveal any evidence of hippocampal cell loss after status epilepticus in either group. Malnutrition per se induced an increase in the genesis of new cells in the anterior dentate granule cell layer. Although exposure to status epilepticus augmented the expression of new cells in the dentate gyrus in both groups, this expression was more pronounced in the malnourished group.Conclusions: The findings suggest that malnutrition early in life alters dentate plasticity but not the susceptibility to flurothy1 seizures. Although status epilepticus can increase the expression of new cells in the dentate gyrus in immature rats, malnutrition followed by status epilepticus further increases dentate granule cell proliferation. Key Words: EpilepsyMalnutrition-Plasticity-CNS development-Hippocampus-Dentate gyrus.Malnutrition is one of the most important health problems in developing and underdeveloped countries. Nutritional insults early in life have a profound and often permanent effect on the subsequent development of the central nervous system. Clinical studies indicate that malnourished children have more learning and behavioral problems than well-nourished children (1-3). In a cross-sectional study from a pediatric population residing in a governmental institution, there was a trend toward a greater number of epilepsy cases among malnourished children compared with controls (4). However, a direct relationship between malnutrition and epilepsy has not been established in clinical studies.Many animal studies suggest that malnutrition may have detrimental effects on the brain and predispose the A decrease in the number of dendritic spines of pyramidal neurons of lamina I11 or V of the anterior cingulate cortex and in the CA3 hippocampal region was also described (6,7). Furtherm...

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Section: Malnutrition Paradigmmentioning

confidence: 99%

Malnutrition Increases Dentate Granule Cell Proliferation in Immature Rats After Status Epilepticus

et al. 2000

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“…Pups were scattered in the home cage opposite the nest and subject-litter interactions were continuously recorded for 60 min by an observer unaware of the subject's condition with the aid of a computerized data-acquisition system, similar to that described in detail previously (Stern and Lonstein, 1996). Active behaviors recorded included retrieval of the pups into the nest, sniffing the pups, full body and anogenital licking of the pups (both types combined), mouthing (short distanced oral repositioning of the pups), selfgrooming, exploration, and nesting/burrowing in the wood shaving bedding.…”

Section: Behavioral Testingmentioning

confidence: 99%

“…Lactating rats that have had their nipples removed or that interact with pups rendered unable to suckle display very little or no kyphosis and less quiescence over pups in any posture. In the absence of suckling-induced quiescence, nonsuckled dams actively hover over pups more and display increased pup licking, self-grooming, and exploration (Lonstein and Stern, 1997a,b;Lonstein, Simmons, Swann, and Stern, 1998;Stern and Johnson, 1990;Stern and Lonstein, 1996;Stern, Dix, Bellomo, and Thramann, 1992). Kyphosis can also be disrupted by destruction of neural sites that transmit (dorsolateral funiculus of spinal cord; Stern, Yu, and Crockett, 1993) or receive (lateral and ventrolateral regions of the caudal midbrain periaqueductal gray (cPAG l,vl ); Lonstein and Stern, 1997a;1998;Lonstein, Simmons, and Stern, 1998) suckling inputs necessary for the mediation of this posture.…”

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confidence: 99%

Comparison of the “Nursing” and Other Parental Behaviors of Nulliparous and Lactating Female Rats

Lonstein

Wagner

Vries

1999

Hormones and Behavior

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“…During the first 10 days after birth female rats vigorously attack intruders in the nest site, and thereafter decline even though lactation continues. Natural decline of maternal aggression after 10 days postpartum, previous study showed no relationship between the physical development and decrease of aggressiveness [51].…”

Section: Nitric Oxide and Maternal Behaviormentioning

confidence: 99%

Maternal Behavior Their Adjustments and Implicated Factors

Pérez-Torrero¹,

Rubio-Navarro²

2015

JBBS

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The maternal behavior in mammals is one of the most stable and highly conserved motivated species-specific behaviors and crucial for reproductive functions. During maternal behavior nursing and feeding are associated factors with survival of mammalian offspring, mammals nurse their newborn in a wide diversity in the behavioral. In the mother relationship the suckling is the behavioral patterns that identified and unified mammals and showed several selected evolutionary conserved behavior. The milk is an important reward for the pups, it ensure the surviving. The quality of maternal behavior is transmitted between generations; the inadequate maternal care has harmful effects in the adulthood individual. The specific maternal pattern modalities differ greatly between species; the human bonding has underlying biological mechanisms similar in mammals. Maternal brain is modified in order to prepare the mother-pup relationship, being crucial for the adequate behavioral display in the mother-pup relationship. A bulk of surrounding factor such as sensorial stimulus, temperature, ultrasonic communication, and reinforcing stimulus determines the quality of the nursing and care of the progeny. Mother care and nursing quality have long lasting effects in adulthood, determining cognitive and behavioral development and some specific psychiatric and psychological condition in human populations.

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Nursing behavior in rats is impaired in a small nestbox and with hyperthermic pups

Cited by 47 publications

References 49 publications

Malnutrition Increases Dentate Granule Cell Proliferation in Immature Rats After Status Epilepticus

Malnutrition Increases Dentate Granule Cell Proliferation in Immature Rats After Status Epilepticus

Comparison of the “Nursing” and Other Parental Behaviors of Nulliparous and Lactating Female Rats

Maternal Behavior Their Adjustments and Implicated Factors

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