NUP98 is fused to HOXA9 in a variant complex t(7;11;13;17) in a patient with AML-M2

NUP98–HOXA9 bearing therapy‐related myeloid neoplasm involves myeloid‐committed cell and induces HOXA5,EVI1, FLT3, and MEIS1 expression

“…To the best of our knowledge, only two Caucasian cases have molecular demonstration of the NUP98–HOXA9 fusion, and neither of them is a therapy‐related leukemia. In this work, we report the involvement of NUP98–HOXA9 in a t‐AML involving both erythroid and myeloid blastic differentiation and overexpression of EVI1 and MEIS1 genes in a Caucasian woman after Ewing's sarcoma.…”

NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytogénétique Hématologique

“…Until now, NUP98 has been found rearranged with 19 different partner genes resulting in in-frame fusion genes subclassified into three groups. The first group is composed of nine genes coding for homeodomain proteins, seven homeotic genes (HOXA9, HOXA11, HOXA13, HOXC11, HOXC13, HOXD11 and HOXD13), [3][4][5] and two class-2 homeobox genes (PRRX1 and PRRX2). 6,7 The second group comprises eight nuclear nonhomeotic genes: the lens epithelium-derived growth factor (LEDGF), [8][9][10][11] the nuclear-receptor binding set domain genes (NSD1), [12][13][14][15][16] and NSD3, 17 the helicase DDX10, 18-21 the topoisomerase TOP1, [22][23][24][25][26] and TOP2B genes, 27 the FN1 gene 28 and the C6orf80 gene.…”

Acute Myelogenous Leukemia with the t(7;7)(p15;p22) Translocation, a Novel Simple Variant of t(7;11)(p15;p15) Translocation: First Description

“…Simple variants of the t(7;11)(p15;p15) translocation have been reported [ 6 , 7 ]. A 52-year-old man with AML (FAB classification M2) had the t(1;11)(q23;p15), add (7)(q22) karyotype [ 6 ].…”

“…Moreover, the overall survival (OS) and disease-free survival (DFS) of the latter patient group are poorer than those of the former patient group [ 3 ]. A simple variant of the t(7;11)(p15;p15) translocation has been reported [ 6 , 7 ]. This article describes a novel case of AML with the t(7; 7)(p15;p22) translocation and a literature review of the t(7;11)(p15;p15) translocation.…”