Numerosol A–D, New Cembranoid Diterpenes from the  Soft Coral Sinularia numerosa

Tseng, Yen-Ju; Yang, Yuan-Chien; Wang, Shang‐Kwei; Duh, Chang‐Yih

doi:10.3390/md12063371

Cited by 13 publications

(9 citation statements)

References 14 publications

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“…Norcembran sinugyrosanolide dihasilkan S. gyrosa (Cheng et al, 2014). Senyawa diterpen Numerosol A-D (1-4) diperoleh pada S. numerosa dari perairan Taiwan (Tseng et al, 2014). Senyawa Sinulolides A-H (1-8) berhasil diisolat dari spesies Sinularia sp (Yang et al, 2014).…”

Section: Pembahasanunclassified

BACTERIAL SYMBIONT BIOACTIVE COMPOUND OF SOFT CORAL Sinularia flexibilis AND S. polydactyla

Rozirwan

Bengen

Chaidir

et al. 2016

J. Ilmu dan Teknologi Kelautan Tropis

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Symbiont bacteria on soft coral can produce bioactive compounds that plays an important role in chemical ecology and as a marine natural product. The purpose of this study was to find and characterize the antibacterial activities of active compounds extracted from bacterial symbionts of soft coral S. flexibilis and S. polydactyla. The methods used in this study were culture and isolation of bacterial symbionts, extraction of compounds, antibacterial bioassay, and identification of bioactive compounds using the LC-MS analyses. Four isolates of bacterial symbionts were obtained from two samples of soft corals, 2 isolates of Pseudomonas diminuta (A1) and Edwardsiellla hoshinae (A2) from soft coral S. flexibilis, and 2 isolates of E. hoshinae (B1) and P. acidovorans (B4) from S. polydactila. Antibacterial activity were found only from the extracts of bacterial symbionts P. diminuta (A1) and from S. flexiblis about 10.16 ± 0.3mm (for B. subtilis), 8.66 ± 0.8 mm (E. coli) and 9.86 ± 1.7mm (S. dysentri). No antibacterial activity found from the extracts of S. polydactyla. The results of LC MS analysis showed that the group of diterpenes sinularin produced by soft corals S. flexibilis and bacterial symbionts isolates of P. diminuta (A1).Keywords: Bacterial Symbiont, Bioactive Compound, Antibacterial Activity, Soft Coral, Sinularia flexibilis, Sinularia polydactyla

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Section: Pembahasanunclassified

BACTERIAL SYMBIONT BIOACTIVE COMPOUND OF SOFT CORAL Sinularia flexibilis AND S. polydactyla

Rozirwan

Bengen

Chaidir

et al. 2016

J. Ilmu dan Teknologi Kelautan Tropis

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“…From the experience of searching bioactive metabolites from soft corals, series of cembranoids have been unveiled from octocorals (Alcyonaceae) belonging to the genera Sarcophyton , [1,2,3,4,5,6,7,8,16], Sinularia [9,10,11,12,17,18] and Lobophyton [13,14,15]. Also, previous studies showed that two cembranoid units could form biscembranoid-type compounds by Diels-Alder reaction [19,20,21], radical dimerization [22,23], or connection with a sulfur atom [18], making the chemistry of cembranes more complex and interesting than monomeric form.…”

Section: Introductionmentioning

confidence: 99%

New Cembranoids and a Biscembranoid Peroxide from the Soft Coral Sarcophyton cherbonnieri

et al. 2018

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Six new cembranoids, cherbonolides A−E (1–5) and bischerbolide peroxide (6), along with one known cembranoid, isosarcophine (7), were isolated from the Formosan soft coral Sarcophyton cherbonnieri. The structures of these compounds were elucidated by detailed spectroscopic analysis and chemical methods. Compound 6 was discovered to be the first example of a molecular skeleton formed from two cembranoids connected by a peroxide group. Compounds 1–7 were shown to have the ability of inhibiting the production of superoxide anions and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced human neutrophils.

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“…Soft corals of the genus Sinularia have yielded series of natural products of differing chemical types [ 1 ]. Many of these compounds have been shown to exhibit interesting bioactivities, such as cytotoxic [ 2 , 3 , 4 , 5 , 6 , 7 , 8 ], antifouling [ 9 ], and anti-inflammatory [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ] activities. Previous chemical investigation of the wild-type soft coral Sinularia brassica (May 1898) has led to the isolation of only two new steroids from this marine organism [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Bioactive Steroids with Methyl Ester Group in the Side Chain from a Reef Soft Coral Sinularia brassica Cultured in a Tank

Huang

Liaw

et al. 2017

Marine Drugs

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A continuing chemical investigation of the ethyl acetate (EtOAc) extract of a reef soft coral Sinularia brassica, which was cultured in a tank, afforded four new steroids with methyl ester groups, sinubrasones A–D (1–4) for the first time. In particular, 1 possesses a β-d-xylopyranose. The structures of the new compounds were elucidated on the basis of spectroscopic analyses. The cytotoxicities of compounds 1–4 against the proliferation of a limited panel of cancer cell lines were assayed. The anti-inflammatory activities of these new compounds 1–4 were also evaluated by measuring their ability to suppress superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced human neutrophils. Compounds 2 and 3 were shown to exhibit significant cytotoxicity, and compounds 3 and 4 were also found to display attracting anti-inflammatory activities.

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Numerosol A–D, New Cembranoid Diterpenes from the Soft Coral Sinularia numerosa

Cited by 13 publications

References 14 publications

BACTERIAL SYMBIONT BIOACTIVE COMPOUND OF SOFT CORAL Sinularia flexibilis AND S. polydactyla

BACTERIAL SYMBIONT BIOACTIVE COMPOUND OF SOFT CORAL Sinularia flexibilis AND S. polydactyla

New Cembranoids and a Biscembranoid Peroxide from the Soft Coral Sarcophyton cherbonnieri

Bioactive Steroids with Methyl Ester Group in the Side Chain from a Reef Soft Coral Sinularia brassica Cultured in a Tank

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