PACS numbers: 52.25.Xz; 52.30.Cv; 52.25.Fi.A possible mechanism of Edge Localized Modes (ELMs) mitigation by Resonant Magnetic Perturbations (RMPs) is proposed based on the results of non-linear resistive MHD modelling using the JOREK code, Realistic JET-like plasma parameters and RMP spectrum of JET error-field correction coils (EFCC) with main toroidal number n=2 were used in the simulations. Without RMPs, a large ELM relaxation is obtained mainly due to the most unstable medium-n ballooning mode. The externally imposed RMP drives non-linearly the modes coupled to n=2 RMP which produce small multi-mode relaxations, mitigated ELMs. The modes driven by RMPs exhibit a tearing-like structure and produce additional islands. Mitigated ELMs deposit energy into the divertor mainly in the structures ("footprints") created by n=2 RMPs, however, slightly modulated by other nonlinearly driven even harmonics. The divertor power flux during ELMy phase mitigated by RMPs is reduced almost by a factor of ten. The mechanism of ELM mitigation by RMPs proposed here reproduces generic features of high collisionality RMP experiments, where large ELMs are replaced by small much more frequent ELMs or magnetic turbulence. Total ELMs suppression was also demonstrated in modelling at higher RMP amplitude.1.Introduction. The aim of the ITER project is the demonstration of the scientific feasibility of nuclear fusion reactor based on a magnetic confinement concept as a future source of energy [1]. Plasma edge magneto-hydro-dynamic (MHD) instabilities, such as ELMs driven by the pressure gradient and the plasma current produce quasi-periodic relaxations of the edge density and temperature profiles on few hundred microseconds time scale. ELMs in ITER are predicted to lead to the transient heat fluxes reaching tens of GWm -2 which would cause strong erosion of the PFC materials [1-2], hence ELMs control is mandatory in ITER. Recently the application of Resonant Magnetic Perturbations (RMPs) demonstrated the possibility of total ELMs suppression or strong mitigation of their size [3][4][5][6][7][8][9], motivating the use of this method in ITER [1]. In the last decade, the non-linear MHD theory and modeling have made a significant progress to refine the understanding of ELM [10][11][12][13][14] and RMP [15][16][17][18][19][20] physics. However the understanding of RMP interaction with ELMs is still missing and was not modeled so far, motivating work we are presenting here. One can clearly distinguish two groups of RMP experiments. At high collisionality the application of RMPs usually leads to the replacement of large ELMs by small frequent ELMs or MHD turbulence, the divertor power loads are reduced by RMPs. Small changes in edge pressure gradient and MHD stability are reported [3][4][5][6][7][8]. On the other hand, at low collisionality resulting from strong density pump-out due to RMPs, ELMs have been totally suppressed in DIII-D and the plasma edge appears to be stable to peeling/ballooning modes [9]. In the present Letter we report on the...