Variability of temperature and salinity as well as quantifying global trends are fundamental for understanding changes in the Earth's climate. In current paper, a long-term variability of the hydrological regime of the Sea of Azov for 1913–2018 is studied. On the basis of oceanographic information, the seasonal variability of temperature and salinity by the areas of the Sea of Azov is analysed. Temperature anomalies have been revealed, periods of salinization and desalination of the Sea of Azov have been noted and linear trends of the anomaly have been obtained.