Foundation settlement is a common problem in civil engineering. In the case of un-even settlement, it can lead to structural de-formation and damage, which seriously affects the safety and reliability of the project. Therefore, the influence of adjusting the stiffness of the foundation on un-even settlement was analyzed through finite element analysis to effectively solve un-even settlement. By simulating the settlement of soil under different foundation stiffness and load conditions, the influence of foundation stiffness adjustment on soil de-formation and settlement distribution was analyzed, and its impact on structural safety was evaluated. These studies confirmed that thickened layers could effectively solve the un-even settlement. Within the range of 0.2 to 1.0 meters, the difference in thickness was the greatest. The adjustment of differential settlement by layer thickness was phased and decreased with increasing thickness. Adjusting the stiffness of the foundation could effectively solve un-even settlement, reduce differences in soil settlement, and improve the overall stability and safety of the structure. These results have important guiding significance for the design of foundation and the solution of un-even settlement problems in engineering practice and provide certain reference and basis for further research.