Numerical study of a double-stair-shaped dielectrophoresis channel for continuous on-chip cell separation and lysis using finite element method

Keumarsi, Mohammad Mehdi; Oskouei, Pouria Feyzi; Dezhkam, Rasool; Shamloo, Amir; Vatandoust, Farzad; Amiri, Hoseyn A.

doi:10.1016/j.chroma.2023.463960

Cited by 5 publications

(1 citation statement)

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“…In the context of dielectrophoresis sorting, FEM can be employed to simulate the electric field distribution and the resulting forces acting on particles. This method allows for the accurate modeling of complex geometries and can capture the effects of non-uniform electric fields and various particle properties [30][31][32][33][34]. Instead of directly solving the electric field equations, particle-based methods employ individual particle tracking to simulate dielectrophoresis sorting.…”

Section: Introductionmentioning

confidence: 99%

Modelling of bioparticle separation in the dielectrophoresis microfluidic using the Brinkman flow

Olfat,

Kadivar

2024

Phys. Scr.

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In this study, we numerically investigate the dynamics of bioparticle separation in the dielectrophoretic microfluidic device. The straight section of the microchannel consists of a pair of semicircular electrodes on its up and down walls. The different electric potentials are applied to electric electrodes. In the present study, the electric field distribution is obtained by solving the Laplace equation using the boundary element method. After that, we compute the particle trajectory by solving the Brinkman differential equation by applying the boundary element method. In order to compare the numerical results obtained from the boundary element method, we calculate the trajectory of bioparticles using Newton equation in the presence of dielectrophoresis force. Based on the control parameters, the different sorting regimes have been obtained as a function of particle size, applied electric potential, and electrode shape. We have found a good agreement between two numerical methods. Numerical results indicate that for electric voltage ratio of up electrode to down electrode, $\Phi_u/\Phi_d$, smaller than 8.0, platelets flow through the down outlet. We also found that the circulating tumor cells are trapped in the microfluidic channel when the electric potential ratio larger than the 3.8.

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