Numerical studies of the influence of various geometrical features of a multispiked connecting scaffold prototype on mechanical stresses in peri-implant bone

Uklejewski, R.; Winiecki, M.; Patalas, Adam; Rogala, Piotr

doi:10.1080/10255842.2018.1480759

Cited by 5 publications

(10 citation statements)

References 19 publications

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“…2.5 N/mm 2 with the scaffold spikes embedded in the bone to the half high of the spikes. Such the unit loadability of the MSC-Scaffold corresponds to the middle zone of the elastic range of the stress-strain characteristics of periarticular cancellous bone [24].…”

Section: Resultsmentioning

confidence: 99%

“…Recent investigations on the MSC-Scaffold prototype have included, among others, the examination of possibilities of modifying the interspike structural proosteoconductive potential of the SLM-manufactured MSC-Scaffold [23]. The most influential geometrical features of the MSC-Scaffold to ensure the closest-to-physiological load transfer in the peri-implant bone were determined in numerical simulations [24]. The initial pilot implantation study in an animal model of the structurally functionalized MSC-Scaffold [25] provided promising results; the scaffolding effect was obtained with the MSC-Scaffold preprototypes, and the majority of the interspike pore space was penetrated with newly formed bone tissue, providing primary biological fixation of the MSC-Scaffold preprototypes in the periarticular cancellous bone.…”

Section: Introductionmentioning

confidence: 99%

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First Biomimetic Fixation for Resurfacing Arthroplasty: Investigation in Swine of a Prototype Partial Knee Endoprosthesis

Rogala

Uklejewski

Winiecki

et al. 2019

BioMed Research International

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Resurfacing hip and knee endoprostheses are generally embedded in shallow, prepared areas in the bone and secured with cement. Massive cement penetration into periarticular bone, although it provides sufficient primary fixation, leads to the progressive weakening of peri-implant bone and results in failures. The aim of this paper was to investigate in an animal model the first biomimetic fixation of components of resurfacing arthroplasty endoprostheses by means of the innovative multispiked connecting scaffold (MSC-Scaffold). The partial resurfacing knee arthroplasty (RKA) endoprosthesis working prototype with the MSC-Scaffold was designed for biomimetic fixation investigations using reverse engineering methods and manufactured by selective laser melting. After Ca-P surface modification of bone contacting surfaces of the MSC-Scaffold, the working prototypes were implanted in 10 swines. Radiological, histopathological, and micro-CT examinations were performed on retrieved bone-implant specimens. Clinical examination confirmed very good stability (4 in 5-point Likert scale) of the operated knee joints. Radiological examinations showed good implant fixation (radiolucency less than 2 mm) without any signs of migration. Spaces between the MSC-Scaffold spikes were penetrated by bone tissue. The histological sections showed newly formed trabecular bone tissue between the spikes, and the trabeculae of periscaffold bone were seen in contact with the spikes. The micro-CT results showed the highest percentage of bone tissue ingrowths into the MSC-Scaffold at a distance of 2.5÷3.0 mm from the spikes bases. The first biomimetic fixation for resurfacing arthroplasty was successfully verified in 10 swines investigations using RKA endoprosthesis working prototypes. The performed research shows that the MSC-Scaffold allows for cementless and biomimetic fixation of resurfacing endoprosthesis components in periarticular cancellous bone.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

First Biomimetic Fixation for Resurfacing Arthroplasty: Investigation in Swine of a Prototype Partial Knee Endoprosthesis

Rogala

Uklejewski

Winiecki

et al. 2019

BioMed Research International

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“…Our research group designed, developed, and prototyped, through bioengineering research, the essential innovation for a fixation method of RA endoprostheses components in periarticular trabecular bone by means of an innovative multi-spiked connecting scaffold (MSC-Scaffold) [ 9 , 10 , 11 , 12 ]. The MSC-Scaffold concept was proposed by a member (orthopaedic surgeon) of the research group [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…Computational studies on the influence of various geometrical features of an initially embedded MSC-Scaffold on mechanical stresses in peri-implant bone have revealed the features that determine the appropriate MSC-Scaffold design [ 12 ]. Before planned experimental surgical treatment with this new type of hip endoprosthesis in humans, it is crucial to develop a validated numerical model for the bioengineering design of this new kind of biomimetic fixation in the bone of resurfacing endoprostheses components.…”

Section: Introductionmentioning

confidence: 99%

Bone Density Micro-CT Assessment during Embedding of the Innovative Multi-Spiked Connecting Scaffold in Periarticular Bone to Elaborate a Validated Numerical Model for Designing Biomimetic Fixation of Resurfacing Endoprostheses

et al. 2021

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Our team has been working for some time on designing a new kind of biomimetic fixation of resurfacing endoprostheses, in which the innovative multi-spiked connecting scaffold (MSC-Scaffold) that mimics the natural interface between articular cartilage and periarticular trabecular bone in human joints is the crucial element. This work aimed to develop a numerical model enabling the design of the considered joint replacement implant that would reflect the mechanics of interacting biomaterials. Thus, quantitative micro-CT analysis of density distribution in bone material during the embedding of MSC-Scaffold in periarticular bone was applied. The performed numerical studies and corresponding mechanical tests revealed, under the embedded MSC-Scaffold, the bone material densification affecting its mechanical properties. On the basis of these findings, the built numerical model was modified by applying a simulated insert of densified bone material. This modification led to a strong correlation between the re-simulation and experimental results (FVU = 0.02). The biomimetism of the MSC-Scaffold prototype that provided physiological load transfer from implant to bone was confirmed based on the Huber–von Mises–Hencky (HMH) stress maps obtained with the validated finite element (FE) model of the problem. The micro-CT bone density assessment performed during the embedding of the MSC-Scaffold prototype in periarticular bone provides insight into the mechanical behaviour of the investigated implant-bone system and validates the numerical model that can be used for the design of material and geometric features of a new kind of resurfacing endoprostheses fixation.

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“…In contrast to traditional long-stem total hip replacement (THR) endoprostheses requiring surgical removal of the femoral head and neck, for the current generation of THRA endoprostheses, the femoral head is not removed, but is instead trimmed and capped with metal components fixed in subchondral bone with cement and a short stem placed in the femoral neck [1,2]. An essential innovation in the fixation technique for components of THRA endoprostheses in the periarticular trabecular bone—entirely cementless interfacing by means of the biomimetic multi-spiked connecting scaffold (MSC-Scaffold)—was designed, manufactured, structurally and geometrically functionalized, and tested in our previous research [3,4,5,6,7,8]. The concept of multi-spiked (needle-palisade) fixation of RA endoprostheses components in bone was invented by Rogala [9,10,11].…”

Section: Introductionmentioning

confidence: 99%

Native Osseous CaP Biomineral Coating on a Biomimetic Multi-Spiked Connecting Scaffold Prototype for Cementless Resurfacing Arthroplasty Achieved by Combined Electrochemical Deposition

et al. 2019

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The multi-spiked connecting scaffold (MSC-Scaffold) prototype with spikes mimicking the interdigitations of articular subchondral bone is an essential innovation in surgically initiated fixation of resurfacing arthroplasty (RA) endoprosthesis components. This paper aimed to present a determination of the suitable range of conditions for the calcium phosphate (CaP) potentiostatic electrochemical deposition (ECDV=const) on the MSC-Scaffold prototype spikes to achieve a biomineral coating with a native Ca/P ratio. The CaP ECDV=const process on the MSC-Scaffold Ti4Al6V pre-prototypes was investigated for potential VECDfrom −9 to −3 V, and followed by 48 h immersion in a simulated body fluid. An acid–alkaline pretreatment (AAT) was applied for a portion of the pre-prototypes. Scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) and X-ray diffraction (XRD) studies of deposited coatings together with coatings weight measurements were performed. Themost suitable VECD range, from −5.25 to −4.75 V, was determined as the native biomineral Ca/P ratio of coatings was achieved. AAT increases the weight of deposited coatings (44% for VECD = −5.25 V, 9% for VECD = −5.00 V and 15% for VECD = −4.75 V) and the coverage degree of the lateral spike surfaces (40% for VECD = −5.25 V, 14% for VECD = −5.00 V and 100% for VECD = −4.75 V). XRD confirmed that the multiphasic CaP coating containing crystalline octacalcium phosphate is produced on the lateral surface of the spikes of the MSC-Scaffold. ECDV=const preceded by AAT prevents micro-cracks on the bone-contacting surfaces of the MSC-Scaffold prototype, increases its spikes’ lateral surface coverage, and results in the best modification effect at VECD = −5.00 V. To conclude, the biomimetic MSC-Scaffold prototype with desired biomineral coating of native Ca/P ratio was obtained for cementless RA endoprostheses.

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Numerical studies of the influence of various geometrical features of a multispiked connecting scaffold prototype on mechanical stresses in peri-implant bone

Cited by 5 publications

References 19 publications

First Biomimetic Fixation for Resurfacing Arthroplasty: Investigation in Swine of a Prototype Partial Knee Endoprosthesis

First Biomimetic Fixation for Resurfacing Arthroplasty: Investigation in Swine of a Prototype Partial Knee Endoprosthesis

Bone Density Micro-CT Assessment during Embedding of the Innovative Multi-Spiked Connecting Scaffold in Periarticular Bone to Elaborate a Validated Numerical Model for Designing Biomimetic Fixation of Resurfacing Endoprostheses

Native Osseous CaP Biomineral Coating on a Biomimetic Multi-Spiked Connecting Scaffold Prototype for Cementless Resurfacing Arthroplasty Achieved by Combined Electrochemical Deposition

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