In this study, the homotopy perturbation sumudu transform method (HPSTM) is employed to find the analytical fuzzy solution of nonlinear fuzzy integro-differential equations (FIDEs). The solutions of FIDEs are more generalized and have better applications. The fuzzy concept is used to overrule the uncertainty in physical models. Based on the parametric form of the fuzzy number, the nonlinear integro-differential equation (IDE) is converted into two systems of nonlinear IDEs of the second kind. Some numerical examples were solved to demonstrate the efficiency and capability of the method. Graphical representations reveal the symmetry between lower and upper cut representations of fuzzy solutions and may be helpful for a better understanding of fuzzy control models, artificial intelligence, medical science, quantum optics, measure theory, and so on.