The mechanism of the position-mode side guide in correcting slab centerline profile and camber in the roughing process of a hot strip mill (HSM) was analyzed using finite element simulation. The finite element model was established based on the actual size of the roughing mill and on the actual actuating time sequence of the roughing mill in China Steel Corporation (CSC), Kaohsiung. This work could be the first to give an insight into the mechanism of side guides in correcting the slab camber. Time sequence analysis was explored to visualize the progress of centerline profile variation and the interaction between the slab and the related roughing mill components at different moments. The history of reaction forces exerted on the slab was analyzed to explain the interaction between roughing mill components and the slab. The effect of the separation distance of side guide and the effect of the slab wedge on the centerline profile was investigated. A schematic model illustrating the reactions and the resulting moments exerted on the slab was created. By examining the force history, the cross-sectional strain/stress distribution, and the roll force across the horizontal roller, the correcting mechanism of the side guide could be elucidated. The simulation results provide further knowledge in selection and dimension design of side guide to improve the effectiveness of side guide in correcting the slab profile.