Numerical simulation of the transport of nanoparticles as drug carriers in hydromagnetic blood flow through a diseased artery with vessel wall permeability and rheological effects

Tripathi, Jayati; Vasu, B.; Bég, O. Anwar; Mounika, B.; Gorla, Rama Subba Reddy

doi:10.1016/j.mvr.2021.104241

Cited by 12 publications

(4 citation statements)

References 44 publications

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“…Some concerns include their potential toxicity, potential interference with the body's natural defense mechanisms, and potential release into the environment. Tripathi et al [29] conducted research examining the effects of nanoparticles on blood flow rheology in a tapered artery with stenosis. This study raises awareness about the potential risks and challenges that need to be addressed when considering the application of nanoparticles in medical treatments.…”

Section: Introductionmentioning

confidence: 99%

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MHD flow of the novel quadruple hybrid nanofluid model in a stenosis artery with porous walls and thermal radiation: A Sisko model‐based analysis

Omama,

Arafa,

Elsaid

et al. 2024

Z Angew Math Mech

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This study introduces a mathematical model that describes the Magnetohydrodynamics (MHD) flow of blood in a porous stenosis artery, incorporating a new hybrid nanofluid (HNF) model known as ‘Quadruple’ or the tetra‐(HNF) model. An innovative aspect of this study lies in the unexplored combination of tetra‐hybrid nanoparticles with the Sisko rheological model. The conventional Tiwari and Das (HNF) model has been expanded to accommodate the tetra‐(HNFs) case. To transform the governing partial differential equations into ordinary differential equations, a series of variable similarity transformations are employed. The resulting highly nonlinear simultaneous equations are efficiently solved using the shooting method. Numerical computations are conducted to investigate various parametric conditions, and graphs are utilized to visualize notable aspects of flow velocity and temperature. A comprehensive analysis is provided to illustrate the influence of flow parameters on wall shear stress and local Nusselt number, which are depicted through figures and tables. The study shows that the novel tetra‐HNF exhibits enhancements in blood flow when compared to nanofluids with a lower number of hybrids. Increasing the flow power index of non‐Newtonian Sisko model leads to improve convective heat transfer. Furthermore, parameters such as porosity, thermal radiation, and magnetic effects exhibit noticeable impacts on blood flow, temperature, and associated risks in constricted arteries.

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Section: Introductionmentioning

confidence: 99%

“…Tripathi et al. [29] conducted research examining the effects of nanoparticles on blood flow rheology in a tapered artery with stenosis. This study raises awareness about the potential risks and challenges that need to be addressed when considering the application of nanoparticles in medical treatments.…”

Section: Introductionmentioning

confidence: 99%

MHD flow of the novel quadruple hybrid nanofluid model in a stenosis artery with porous walls and thermal radiation: A Sisko model‐based analysis

Omama,

Arafa,

Elsaid

et al. 2024

Z Angew Math Mech

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“…Some recent studies on the blood flow analysis for stenosed arteries are referred to as. [13][14][15] Further, some more relevant scientific literature on blood flow through a stenosed segment with endoscopic catheter applications are provided. [16][17][18][19][20][21][22] Akhtar et al 23 already modeled the steady Casson fluid blood flow problem for a multiple stenosed artery considering cases of both symmetric addition to non-symmetric stenosis and provided an exact solution for the problem.…”

Section: Introductionmentioning

confidence: 99%

CFD analysis on blood flow inside a symmetric stenosed artery: Physiology of a coronary artery disease

et al. 2023

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This research article interprets the computational fluid dynamics analysis on blood flow inside a symmetric stenosed artery. The current problem models the blood flow inside the left coronary artery as having a symmetric stenosis in the central region. A comprehensive physiological examination of coronary artery disease is numerically evaluated by using the computational fluid dynamics toolbox Open-Field Operation And Manipulation. There are no assumptions of mild stenosis taken into account since the considered stenosis has an exactly measured length, height and position, etc. The blood flow problem is modeled for the non-Newtonian Casson fluid with unsteady, laminar, and incompressible flow assumptions. The underlying problem is solved numerically in its dimensional form. A thorough graphical analysis is provided on the blood flow simulations, pressure profile, velocity line graphs, pressure line graphs, and streamlines for the left coronary artery having a symmetric stenosis formation. The considered artery is divided into three sections, i.e. pre-stenosis, post-stenosis, and stenosis region, and the velocity and pressure line graphs are plotted for these considered regions. The graphical illustrations provide a detailed analysis of how the blood flow is affected inside the left coronary artery due to coronary artery disease. These pre- and post-stenosis velocity line graphs reveal two intriguing results: In the pre-stenosis zone, the velocity increases with increasing axial coordinate length, whereas in the post-stenosis region, the velocity decreases with rising axial coordinate length. It is evident that as the flow moves toward the stenosis region, the flow profile rises; yet, after passing through the stenosis zone, the flow profile begins to fall as the flow moves away from the stenosis region.

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“…Huang et al 14 used Fe 3 O 4 magnetic nanoparticles for MRI‐targeted detection in the early lesions of atherosclerosis. Tripathi et al 15 considered the mathematical modeling of unsteady non‐Newtonian hydro‐magnetic nano‐hemodynamics through a rigid cylindrical artery featuring two different stenosis. Gao et al 16 compared the abundance and difference of immune cell subtypes within unstable atherosclerotic tissues.…”

Section: Introductionmentioning

confidence: 99%

The effect of pharmaceutical nanoparticles and atherosclerosis in aorta artery on the instable blood velocity based on numerical method

Motaghedifar

Fakhar

Tabatabaei

et al. 2022

Numer Methods Biomed Eng

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In medicine field, dynamic investigation of aorta artery has received attention due to its notable functions and significance upon performance of heart and individual health. Because, aortic injuries cause lethal occurrences having numerous mortality rates. Therefore, more probes, in particular, dynamic response of aorta arteries conveying blood flow containing pharmaceutical nanoparticles is essential. In present research, we attempt to model biomechanically the dynamic instability assessment of aorta arteries with atherosclerosis in tissue matrix conveying blood including pharmaceutical magnetic nanoparticles. Thus, according to classical cylindrical shell theory, the aorta arteries will be considered as elastic cylindrical vessels and symmetric lipid tissue is utilized in order to model atherosclerosis in the artery. Applying magnetic field to nanoparticles results in attraction of lipid tissue in artery. Moreover, the nature of blood flow is regarded non‐Newtonian based on Casson, Carreau, and power law models. Using Hamilton's principle, the motion equations are derived and based on differential quadrature method, the dynamic instability region of aorta artery is obtained. The influences of different variables such as magnetic field, magnetic nanoparticle's volume percent, combined effects of the tissue, lipid's height and length, and non‐Newtonian models upon dynamic behavior of aorta artery are investigated. According to the results, increase in lipid's height leads to increase in resonance frequency of aorta arteries.

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Numerical simulation of the transport of nanoparticles as drug carriers in hydromagnetic blood flow through a diseased artery with vessel wall permeability and rheological effects

Cited by 12 publications

References 44 publications

MHD flow of the novel quadruple hybrid nanofluid model in a stenosis artery with porous walls and thermal radiation: A Sisko model‐based analysis

MHD flow of the novel quadruple hybrid nanofluid model in a stenosis artery with porous walls and thermal radiation: A Sisko model‐based analysis

CFD analysis on blood flow inside a symmetric stenosed artery: Physiology of a coronary artery disease

The effect of pharmaceutical nanoparticles and atherosclerosis in aorta artery on the instable blood velocity based on numerical method

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