Numerical simulation of the tissue differentiation and corrosion process of biodegradable magnesium implants during bone fracture healing

Ma, Songyun; Zhou, Beixian; Markert, Bernd

doi:10.1002/zamm.201700314

Cited by 19 publications

(27 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The proposed corrosion damage model is implemented via the user material subroutine UMAT in Abaqus Standard. The morphology of the corrosion surface and the information of the neighbour elements are modified and updated during the finite elements simulation by using a developed Python program and the user subroutine UEXTERNALDB in Abaqus [2].…”

Section: Section 2: Biomechanicsmentioning

confidence: 99%

Computational study of the interaction between degradation of biodegradable magnesium implants and bone remodelling

Markert

2018

Proc Appl Math and Mech

Self Cite

View full text Add to dashboard Cite

Biodegradable magnesium implants are increasingly applied to promising orthopaedic fixation devices due to obvious advantages over conventional permanent implants. However, potential risks of environment assisted corrosion failures during their service in human body have not been systematically studied [1], which leads to a limitation of the extensive applications of the magnesium implants. In addition, the influence of the degradation process of magnesium implants on the bone remodelling after surgery is also a critical factor. Therefore, a modelling approach is required to understand their interactions with the physiological environment and improve the design of biodegradable magnesium implants with respect to the healing efficiency of fractured bones. In the present work, three-dimensional computer simulations are conducted for a fractured femur fixed by the bone plate and screws to investigate the service behaviour of magnesium implants and their interaction with the bone healing process. A mechano-regulatory model based on the biphasic stimuli is used to simulate tissue differentiation and bone remodelling of the fractured femur. A corrosion damage model is used to describe the complex degradation process of mechanical integrity of magnesium implants under physiological loadings. The simulation results are consistent with the experimental observation. The present modelling approach provides an efficient tool in the design and the performance evaluation of biodegradable magnesium implants.

show abstract

Section: Section 2: Biomechanicsmentioning

confidence: 99%

Computational study of the interaction between degradation of biodegradable magnesium implants and bone remodelling

Markert

2018

Proc Appl Math and Mech

Self Cite

View full text Add to dashboard Cite

show abstract

“…Biodegradable magnesium alloys are regarded as promising biomaterials of the next-generation orthopaedic implants. Due to the degradation ability in physiological environments, biodegradable orthopaedic fixation systems potentially avoid a second surgery for implant removal [1]. Despite these advantages, a number of fundamental problems have to be solved for promoting the development and breakthrough of biodegradable magnesium implants.…”

Section: Introductionmentioning

confidence: 99%

Phase field modelling of stress assisted corrosion of biodegradable magnesium alloys

Zhang

Markert

2019

Proc Appl Math and Mech

Self Cite

View full text Add to dashboard Cite

Biodegradable magnesium alloys are regarded as promising biomaterials for orthopaedic fixation devices due to obvious advantages over conventional permanent implants. Experimental studies have shown that the stress state has a significant impact on the corrosion rate of biodegradable magnesium alloys. In the present work, the phase field modelling approach is used to simulate the stress assisted corrosion of biodegradable magnesium alloys with porous microstructures. The simulation results demonstrates effects of the porous microstructure on the degradation behaviour of biodegradable magnesium implants.

show abstract

“…An obvious way in which biomechanics will have a clinical impact over the next decades is through computational results that provide a sound basis for the design of biomedical devices and implants. The study [] illustrates this concept by discussing how the degradation of magnesium implants in vivo can be modeled in silico, which is an important step towards the computer‐aided design of biodegradable magnesium implants. However, mathematical and computational modeling in biomechanics cannot only help design devices and implants but also support the computer‐aided planning of surgical interventions.…”

mentioning

confidence: 99%

Preface of the special issue on mathematical and computational modeling in biomechanics

Holzapfel

Cyron

2018

Z Angew Math Mech

View full text Add to dashboard Cite

Preface of the special issue on mathematical and computational modeling in biomechanicsBiomechanics is one of the fastest growing areas of mechanics research. While less than 1000 researchers participated in the 3 rd World Congress on Biomechanics in 1998, more than 4000 participants were counted at the 8 th World Congress on Biomechanics held in 2018 in Dublin, which makes biomechanics nowadays one of the largest research communities in the area of mechanics. The fast rising number of scientists working in biomechanics is in the first place the consequence of a change of paradigm that has taken place in life sciences mainly over the last three decades. For centuries, biochemistry was considered the primary subject area for understanding the functioning of living organisms. However, the recent rise of mechanobiology has revealed that many of the most fundamental mechanisms in living organisms are in fact not -or at least not exclusively -controlled biochemically but rather mechanically. Unraveling the role of mechanics in living organisms has proven to be highly rewarding but also highly challenging. In particular, due to ethical concerns and the inherent complexity of living organisms, experiments in biomechanics usually take much more time and resources than in classical mechanics. Mathematical and computational modeling can be the key for reducing experimental efforts. Developing and using this key can be expected to be one of the most promising areas of research for investigators in mechanics and applied mathematics over the next decades. This special issue in ZAMM seeks to cover the whole range of questions and problems in biomechanics from fundaments to clinical research.Given the above-mentioned key role of mechanobiology in the fast rise of biomechanics over the last decades, it is natural that many of the articles in this special issue focus specifically not only on mechanical aspects alone but rather on the interplay between mechanical and biological processes, that is, on mechanobiology in the broadest sense. In this special issue, the two probably most prominent sub-areas of mechanobiology are addressed, which are mechano-regulated growth and remodeling of biological tissues and electrophysiologically and biochemically controlled muscular contractions. Within the area of mechanoregulated growth and remodeling, the review article [1] focuses on the cellular and sub-cellular foundations, in particular on cellular mechanotransduction and contractility. These phenomena translate on the tissue scale into characteristic mechano-regulated growth and remodeling processes.[2] and [3] propose novel mathematical models for these processes in arteries. Such models always rely not only on information about the cellular foundations of mechanobiology but also on a detailed understanding of the mechanics of soft biological tissues, which is crucially governed by their fibrous microstructure. Understanding the role of this microstructure during macroscopic tissue deformations remains an ongoing area of research that i...

show abstract

Numerical simulation of the tissue differentiation and corrosion process of biodegradable magnesium implants during bone fracture healing

Cited by 19 publications

References 29 publications

Computational study of the interaction between degradation of biodegradable magnesium implants and bone remodelling

Computational study of the interaction between degradation of biodegradable magnesium implants and bone remodelling

Phase field modelling of stress assisted corrosion of biodegradable magnesium alloys

Preface of the special issue on mathematical and computational modeling in biomechanics

Contact Info

Product

Resources

About