Numerical Simulation of the Posterior Malleolus Fracture with the Finite Element Method

Ampla, Rafailia; Vasiliadis, Angelo V.; Katakalos, Konstantinos

doi:10.3390/jfb11010014

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…There are many other possible applications, which could be applied for designing and testing of other implant models such as hip, knee, wrist, ankle, and spine. [18][19][20][21][22][23][24][25][26][27] A similar methodology to that explained in this paper could be utilized for teaching of FEM to BME students.…”

Section: Discussion Evaluation Of the Questionnairementioning

confidence: 99%

Towards Integration of the Finite Element Modeling Technique Into Biomedical Engineering Education

Mihçin

Ciklacandir

2021

Biomed. Eng. Appl. Basis Commun.

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Biomedical engineering (BME) is a multidisciplinary field, resulting in a heavy course load from different fields. We hypothesize that the engineering curriculum be tailored according to the requirements of the BME profession. In this study, we focus on the teaching of the finite element modeling (FEM) technique by redesigning the course to address the needs of the BME profession by some custom-made changes to meet the unmet needs. After the completion of the course, evaluation methods of the students were analyzed and detailed over a survey providing feedback from the students. The surveys were related to the teaching the theory of FEM, the laboratory sessions, and the project sessions. The survey results were evaluated using statistical methods. The Pearson correlation coefficient showed a linear agreement between theoretical and practical sessions indicating efficient blending of skills because of the custom-made changes. The survey analysis showed that the students were in favour of the changes, allowing them to be more resourceful and confident with their skills. The positive results indicate a positive attitude among the students towards their profession. As the course design addresses the needs of the profession allowing students to fit in better, the students might follow their own profession after graduation. A wider follow-up study might be planned next to compare the results between who received tailor-designed courses and those who did not.

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Section: Discussion Evaluation Of the Questionnairementioning

confidence: 99%

Towards Integration of the Finite Element Modeling Technique Into Biomedical Engineering Education

Mihçin

Ciklacandir

2021

Biomed. Eng. Appl. Basis Commun.

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“…After implantation, the ideal scaffold must elicit a negligible immune response, in order to avoid severe inflammatory responses that might reduce healing properties and/or cause material rejection [ 8 , 19 ]. Beyond their safety, scaffolds should provide appropriate structural support, and in certain cases, biomechanical cues, to promote the safe and effective reconstruction of a functional tissue in vivo [ 9 , 10 , 20 ]. A way to promote scaffold integration is to modify the chemical backbone of the biomaterial or the physicochemical properties of the surface to influence cell adhesion, migration, proliferation and differentiation in vivo [ 21 ].…”

Section: Requirements Of Scaffold For Tendon Repairmentioning

confidence: 99%

“…In this regard, tissue engineering strategies, including the concept of scaffold induced endogenous tissue repair, have gained popularity due to their assured biocompatibility and bioactivity [ 1 , 8 ]. Scaffolds can be used as a suitable platform, which permits cell-biomaterial interactions, cell adhesion, proliferation, and differentiation, while provoking a minimal degree of immune response [ 1 , 9 , 10 ]. Preliminary studies have shown that scaffolds may be used as an alternative augmentation, associated with significant therapeutic potential [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Scaffolds in Tendon Tissue Engineering

Vasiliadis

Katakalos

2020

JFB

Self Cite

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Tendons are unique forms of connective tissue aiming to transmit the mechanical force of muscle contraction to the bones. Tendon injury may be due to direct trauma or might be secondary to overuse injury and age-related degeneration, leading to inflammation, weakening and subsequent rupture. Current traditional treatment strategies focus on pain relief, reduction of the inflammation and functional restoration. Tendon repair surgery can be performed in people with tendon injuries to restore the tendon’s function, with re-rupture being the main potential complication. Novel therapeutic approaches that address the underlying pathology of the disease is warranted. Scaffolds represent a promising solution to the challenges associated with tendon tissue engineering. The ideal scaffold for tendon tissue engineering needs to exhibit physiologically relevant mechanical properties and to facilitate functional graft integration by promoting the regeneration of the native tissue.

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Microfluidically Aligned Collagen to Maintain the Phenotype of Tenocytes In Vitro

Giacomini,

Baião Barata,

Suk Rho

et al. 2023

Adv Healthcare Materials

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Tendon is a highly organized tissue that transmits forces between muscle and bone. The architecture of the extracellular matrix of tendon, predominantly from collagen type I, is important for maintaining tenocyte phenotype and function. Therefore, in repair and regeneration of damaged and diseased tendon tissue, it is crucial to restore the aligned arrangement of the collagen type I fibers of the original matrix. To this end, a novel, user‐friendly microfluidic piggyback platform is developed allowing the controlled patterned formation and alignment of collagen fibers simply on the bottom of culture dishes. Rat tenocytes cultured on the micropatterns of aligned fibrous collagen exhibit a more elongated morphology. The cells also show an increased expression of tenogenic markers at the gene and protein level compared to tenocytes cultured on tissue culture plastic or non‐fibrillar collagen coatings. Moreover, using imprinted polystyrene replicas of aligned collagen fibers, this work shows that the fibrillar structure of collagen per se affects the tenocyte morphology, whereas the biochemical nature of collagen plays a prominent role in the expression of tenogenic markers. Beyond the controlled provision of aligned collagen, the microfluidic platform can aid in developing more physiologically relevant in vitro models of tendon and its regeneration.This article is protected by copyright. All rights reserved

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Numerical Simulation of the Posterior Malleolus Fracture with the Finite Element Method

Cited by 4 publications

References 19 publications

Towards Integration of the Finite Element Modeling Technique Into Biomedical Engineering Education

Towards Integration of the Finite Element Modeling Technique Into Biomedical Engineering Education

The Role of Scaffolds in Tendon Tissue Engineering

Microfluidically Aligned Collagen to Maintain the Phenotype of Tenocytes In Vitro

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