Numerical simulation of the blood flow through the coronary artery stenosis: Effects of varying eccentricity

Timofeeva, Mariia; Ooi, Andrew; Poon, Eric; Barlis, Peter

doi:10.1016/j.compbiomed.2022.105672

Cited by 20 publications

(15 citation statements)

References 25 publications

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“…In the PSR 70% model, it is 6.73e4 Pa at low pulse and 9.51e4 Pa at high pulse. As stated in previous validated studies, endothelial cells located on the inner surface of the artery wall sense and transform the irregular pressure into signals, ensuring the stability of the vascular environment 61–63 . As blood passes through the stenosed artery, it needs more energy due to the sudden drop in pressure.…”

Section: Resultsmentioning

confidence: 92%

“…As stated in previous validated studies, endothelial cells located on the inner surface of the artery wall sense and transform the irregular pressure into signals, ensuring the stability of the vascular environment. [61][62][63] As blood passes through the stenosed artery, it needs more energy due to the sudden drop in pressure. The continuous effect of the pressure difference caused by stenosis makes it easy for lipid substances carried in the blood to accumulate in low pressure areas.…”

Section: Cfd Analysismentioning

confidence: 99%

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Experimental and numerical investigation of the stenosed coronary artery taken from the clinical setting and modeled in terms of hemodynamics

Sonmez,

Karagoz,

Yildirim

et al. 2023

Numer Methods Biomed Eng

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The study was carried out to investigate the effect of the artery with different pulse values and stenosis rates on the pressure drop, the peristaltic pump outlet pressure, fractional flow reserve (FFR) and most importantly the amount of power consumed by the peristaltic pump. For this purpose, images taken from the clinical environment were produced as models (10 mm inlet diameter) with 0% and 70% percent areal stenosis rates (PSR) on a three‐dimensional (3D) printer. In the experimental system, pure water was used as the fluid at 54, 84, 114, 132, and 168 bpm pulse values. In addition, computational fluid dynamics (CFD) analyzes of the test region were performed using experimental boundary conditions with the help of ANSYS‐Fluent software. The findings showed that as PSR increases in the arteries, the pressure drop in the stenosis region increases and this amount increases dramatically with increasing effort. An increase of approximately 40% was observed in the pump outlet pressure value from 54 bpm to 168 bpm in the PSR 0% model and 51% increase in the PSR 70% model. It has been observed that the pump does more work to overcome the increased pressure difference due to increased pulse rate and PSR. With the effect of contraction, the power consumption of the pump increased from 9.2% for 54 bpm to 13.8% for 168 bpm. In both models, the Wall Shear Stress (WSS) increased significantly. WSS increased abruptly in the stenosis and arcuate regions, while sudden decreases were observed in the flow separation region.

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Section: Resultsmentioning

confidence: 92%

Section: Cfd Analysismentioning

confidence: 99%

Experimental and numerical investigation of the stenosed coronary artery taken from the clinical setting and modeled in terms of hemodynamics

Sonmez,

Karagoz,

Yildirim

et al. 2023

Numer Methods Biomed Eng

View full text Add to dashboard Cite

show abstract

“…Relative residence time (RRT) gives a relative estimation of the residence time of the fluid in an area. Its value increases in the areas where the near-wall velocity has large direction changes but small magnitude over one period [ 29 ]. RRT is computed according to the following formulas: where T is the period of the cardiac cycle, and WSS is the WSS vector.…”

Section: Methodsmentioning

confidence: 99%

Time-resolved simulation of blood flow through left anterior descending coronary artery: effect of varying extent of stenosis on hemodynamics

Zhao

Chen

Sun

et al. 2023

BMC Cardiovasc Disord

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Background and objectives Real-time blood flow variation is crucial for understanding the dynamic development of coronary atherosclerosis. The main objective of this study is to investigate the effect of varying extent of stenosis on the hemodynamic features in left anterior descending coronary artery. Methods Various Computational fluid dynamics (CFD) models were constructed with patient-specific CT image data, using actual fractional flow reserve (FFR) as boundary conditions to provide a real-time quantitative description of hemodynamic properties. The hemodynamic parameters, such as the local and instantaneous wall shear stress (WSS), oscillating shear index (OSI) and relative residence time (RRT), blood flow velocity and pressure drop during various phases of cardiac cycle were provided in detail. Results There was no evident variation in hemodynamic parameters in the cases of less than 50% stenosis while there were abrupt and dramatic changes in hemodynamics when the stenosis aggravated from 60 to 70%. Furthermore, when the stenosis was beyond 70%, there existed substantial pressure difference, WSS, and blood flow velocity in the center of the stenosis. Although OSI and RRT increased along with the aggravation of stenosis, they appeared with obvious abnormalities across all cases, even in mild stenosis. Conclusion The simulation could present a dynamic and comprehensive profile of how hemodynamic parameters vary in accordance with divergent severities of stenosis, which could serve as an effective reference for the clinicians to have a deeper insight into the pathological mechanism of coronary atherosclerosis and stenosis.

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“…The stricture severity is defined as:

S_{normalR} = \frac{D - d}{D} \times 100 %

where D is the normal duct diameter and it equals 2 R 0 , and d is the diameter in the stricture. The eccentricity degree is characterized by 38 :

E_{normald} = \frac{h_{1} - h_{2}}{h_{1}} \times 100 %

where h 1 and h 2 are sepecified in Figure 1C. For concentric stricture, there is h 1 = h 2 .…”

Section: Methodsmentioning

confidence: 99%

Analysis and numerical investigation of bile flow dynamics within the strictured biliary duct

Peng,

Zhong,

Lin

et al. 2023

Numer Methods Biomed Eng

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The mechanics of bile flow in the biliary system plays an important role in studying bile stasis and gallstone formation. Bile duct stricture is an abnormal phenomenon that refers to the bile duct getting smaller or narrower. The main objective of this study is to study the influence of stricture on bile flow dynamics using numerical methods. We employed a numerical Computational Fluid Dynamics model of the bile flow within a strictured hepatic duct. We studied and compared the influence of stricture severity, stricture length, eccentricity, and bile flow property on the bile flow dynamics. The bile flow velocity, pressure distribution, pressure drop, and wall shear stress are provided in detail. The stricture alters the normal bile flow pattern and increases flow resistance. At the location upstream and downstream of the stricture, bile flow slows down. In the area of the stricture throat, bile flow is accelerated, and recirculation forms behind the stricture. The maximum pressure drop of the biliary system increases with the stricture length. The eccentricity makes the flow deflect away from the duct's centerline. The behavior of the deflected flow is significantly altered downstream of the stricture. Such bile flow behavior as deceleration and recirculation may lead to cholestasis. Stricture alters bile flow in the biliary tract, causing changes in biliary hydrodynamic indexes, which could potentially serve as an omen for gallstone formation and other related diseases. The consideration of the bile duct stricture could lead to better patient stratification.

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Numerical simulation of the blood flow through the coronary artery stenosis: Effects of varying eccentricity

Cited by 20 publications

References 25 publications

Experimental and numerical investigation of the stenosed coronary artery taken from the clinical setting and modeled in terms of hemodynamics

Experimental and numerical investigation of the stenosed coronary artery taken from the clinical setting and modeled in terms of hemodynamics

Time-resolved simulation of blood flow through left anterior descending coronary artery: effect of varying extent of stenosis on hemodynamics

Analysis and numerical investigation of bile flow dynamics within the strictured biliary duct

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