Numerical simulation of magnetic nanoparticles targeting in a bifurcation vessel

Larimi, Morsal Momeni; Ramiar, Abas; Ranjbar, A.A.

doi:10.1016/j.jmmm.2014.03.002

Cited by 63 publications

(24 citation statements)

References 28 publications

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“…Recently, some researchers have attempted to investigate nanoparticle behavior and possible issues during the guiding phase inside the blood vessel [10]- [12]. In [13], we showed that the sticking of particles to vessel walls is an issue in the transport of the particles towards the target region.…”

Section: Introductionmentioning

confidence: 95%

“…Although adherence of the particles to walls is the main goal in the target region and capturing phase, it is not desirable in the delivery stage and leads to low transport efficiency. In [10] [11] and [12], the adherence of nanoparticles to vessels with a constant magnetic field was examined experimentally and through simulation, respectively. In [13], although sticking was reduced slightly by changing the shape of the magnet, this is not a general solution because the study focused only on the special case of particles sticking at the injection site.…”

Section: Introductionmentioning

confidence: 99%

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An optimized field function scheme for nanoparticle guidance in magnetic drug targeting systems

Duc

Noh

Kim

et al. 2015

2015 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS)

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Abstract-Magnetic drug targeting is an approach to guide and concentrate magnetic nanoparticles (MNPs) into the diseased target organ after being injected into blood vessels. Although many works for drug targeting have been conducted, there are few studies on delivering the nanoparticles to the target region. Drug delivery performance has not been addressed sufficiently or fully. In this paper, we investigate the effect of dominant factors to MNPs delivery performance. Then, an optimized field function scheme with a pulsed magnetic actuation is proposed to significantly improve the MNPs guidance performance. With a specific condition of blood vessel size, particle size, and applied magnetic field, the optimized parameters of the field function are selected through extensive simulation studies. We find out that the optimal negative and positive time for the magnetic pulsed field mainly depends on the exit time for particles to reach the bifurcation and the critical time as the maximum time for them to reach the vessels wall, respectively. With the chosen parameters, we show that ratios of correctly guided particles in a Y-channel are reached to 100%. In addition, to minimize the power consumption, a modified field function (MFF) scheme is introduced. The MFF includes a no-power time, called zero-time, between the positive and negative time. It is shown that with the proposed MFF, the energy consumption and the heating problem of the actuator system can be significantly reduced. Therefore, the proposed guidance scheme for MNPs can overcome the sticking issue and maximize the guidance performance as well as reducing the power consumption. It should be noted that the MFF can be easily implement by programmable DC power supplies connected to electromagnetic coils.

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Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

An optimized field function scheme for nanoparticle guidance in magnetic drug targeting systems

Duc

Noh

Kim

et al. 2015

2015 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS)

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“…where 0 , , M, and H denote permeability of vacuum, volume of magnetic nanoparticles, magnetization of magnetic nanoparticle, and magnetic field intensity, respectively. The magnetization of the magnetic nanoparticle can be calculated using the following expression [32]:…”

Section: The Dispersed Phasementioning

confidence: 99%

Targeting a channel coating by using magnetic field and magnetic nanofluids

Akar

Rashidi

Esfahani

et al. 2018

J Therm Anal Calorim

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In this paper, the magnetic nanofluids and magnetic field are used to provide the coating around the wall of a channel. The magnetic field is induced by the direct current wire. Iron oxide is used as magnetic nanoparticles. A finite volume method is used to solve the Navier stokes equations and the Eulerian-Lagrangian approach is employed to track the magnetic nanoparticles. The effects of magnetic strength, the position of current wire, and the diameter of magnetic nanoparticles on the trajectory of magnetic nanoparticles and coating efficiency are investigated by providing contours are diagrams. The results showed that the length of coating decreases about 55% with increasing the particle diameter in the range of 500 nm to 1 μm. Further, the coating efficiency, defined as the ratio of the number of trapped particles on the wall to the number of injected particles at the inlet of the channel, improves by increasing the magnetic strength and decreasing the vertical position of current wire.

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“…A popular example is guiding particles through a bifurcation blood vessel. For this case many researchers have studied the effect of magnetic field strength, steady state flow, unsteady flow or size and shape of blood vessels [1] on the path of particles. In general two approaches are common to model particles.…”

Section: Introductionmentioning

confidence: 99%

Influence of Hemorheology on Nanoparticle Transport in Vessel Bifurcations

Bavandi

Wünsch

2018

Proc Appl Math and Mech

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This study presents the effect of hemorheology on nanoparticle transport in the left coronary artery. The flow is considered to be pulsating and particles are modeled by concentration equation. The influence of Newtonian and non-Newtonian modeling approaches on particle transport is investigated and compared. Three bifurcations are investigated to determine the effect of bifurcation angles. The results show that considering blood as non-Newtonian in certain configurations is necessary.

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Numerical simulation of magnetic nanoparticles targeting in a bifurcation vessel

Cited by 63 publications

References 28 publications

An optimized field function scheme for nanoparticle guidance in magnetic drug targeting systems

An optimized field function scheme for nanoparticle guidance in magnetic drug targeting systems

Targeting a channel coating by using magnetic field and magnetic nanofluids

Influence of Hemorheology on Nanoparticle Transport in Vessel Bifurcations

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