Numerical simulation of magnetic nano drug targeting in a patient-specific coeliac trunk

Boghi, Andrea; Russo, F.; Gori, Fabio

doi:10.1016/j.jmmm.2017.04.055

Cited by 23 publications

(18 citation statements)

References 48 publications

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“…As far as the outlets are concerned, a mixed BC is employed: when the air leaves the domain the velocity normal derivative is set to zero, whereas the tangential velocity is set to zero when air enters through the boundary. The velocity profile is imposed on the inlet with a parabolic profile in steady state, while a Womersley-Evans profile is employed in unsteady state, in analogy with [10,29],…”

Section: Boundary Conditions (Bc)mentioning

confidence: 99%

“…The present problem has been solved with the mhdB4Foam solver, developed in [29], which couples the Lagrangian particle dynamics with the Eulerian MHD.…”

Section: Numerical Detailsmentioning

confidence: 99%

“…Some Boundary Conditions, such as the resistive BC, the pulsatile profile on the inlet for unsteady state and the parabolic profile for steady state, are implemented through the utility groovyBC, in analogy with [29]. Furthermore, the imposed magnetic field on the domain has been set using the rectMagProbe external OpenFOAM module, developed in [29]. The simulations are carried on for 2 respiratory cycles, considering a period of 1s and a variable time step, in order to guarantee a Courant number smaller than 0.5 during the respiratory cycle.…”

Section: Numerical Detailsmentioning

confidence: 99%

“…Biological effects of electromagnetic fields have been investigated in [22], while the application of the magnetic technique for the transport of drugs and tracers in specific targets has been developed in [23]. Few CFD studies have been conducted to simulate the magnetic drug targeting in blood vessels both in idealized [24][25][26][27] and patient-specific [28,29] geometries. A mathematical model has been proposed in [30] in order to investigate the deposition of magnetic particles aerosol in lung alveolus, by considering only one alveolus with a simplified spherical geometry.…”

Section: Introductionmentioning

confidence: 99%

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Numerical simulation of magnetic nano drug targeting in patient-specific lower respiratory tract

Russo

Boghi

Gori

2018

Journal of Magnetism and Magnetic Materials

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Magnetic nano drug targeting, with an external magnetic field, can potentially improve the drug absorption in specific locations of the body. However, the effectiveness of the procedure can be reduced due to the limitations of the magnetic field intensity. This work investigates this technique with the Computational Fluid Dynamics (CFD) approach. A single rectangular coil generates the external magnetic field. A patient-specific geometry of the Trachea, with its primary and secondary bronchi, is reconstructed from Digital Imaging and Communications in Medicine (DICOM) formatted images, throughout the Vascular Modelling Tool Kit (VMTK) software. A solver, coupling the Lagrangian dynamics of the magnetic nanoparticles with the Eulerian dynamics of the air, is used to perform the simulations. The resistive pressure, the pulsatile inlet velocity and the rectangular coil magnetic field are the boundary conditions. The dynamics of the injected particles is investigated without and with the magnetic probe. The flow field promotes particles adhesion to the tracheal wall. The particles volumetric flow rate in both cases has been calculated. The magnetic probe is shown to increase the particles flow in the target region, but at a limited extent. This behavior has been attributed to the small particle size and the probe configuration.

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Section: Boundary Conditions (Bc)mentioning

confidence: 99%

“…The present problem has been solved with the mhdB4Foam solver, developed in [29], which couples the Lagrangian particle dynamics with the Eulerian MHD.…”

Section: Numerical Detailsmentioning

confidence: 99%

Section: Numerical Detailsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Numerical simulation of magnetic nano drug targeting in patient-specific lower respiratory tract

Russo

Boghi

Gori

2018

Journal of Magnetism and Magnetic Materials

Self Cite

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“…They have developed an optimal magnetic drug characteristics coordination and magnetic impact for drug delivery to the human lung. Boghi et al [27] have studied the influence of magnetic probe position and circulating direction of electric current and geometry they used was the coeliac trunk for describing MNPs in blood flow. They verified that the effectiveness of their technique can be the treatment of hepatic cancer.…”

Section: Introductionmentioning

confidence: 99%

Targeted Drug Delivery of Magnetic Nano-Particle in the Specific Lung Region

2020

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Aerosolized drug inhalation plays an important role in the treatment of respiratory diseases. All of the published in silico, in vivo, and in vitro studies have improved the knowledge of aerosol delivery in the human respiratory system. However, aerosolized magnetic nano-particle (MNP) transport and deposition (TD) for the specific position of the human lung are still unavailable in the literature. Therefore, this study is aimed to provide an understanding of the magnetic nano-particle TD in the targeted region by imposing an external magnetic field for the development of future therapeutics. Uniform aerosolized nano-particle TD in the specific position of the lung airways will be modelled by adopting turbulence k–ω low Reynolds number simulation. The Euler–Lagrange (E–L) approach and the magneto hydrodynamics (MHD) model are incorporated in the ANSYS fluent (18.0) solver to investigate the targeted nano-particle TD. The human physical activity conditions of sleeping, resting, light activity and fast breathing are considered in this study. The aerosolized drug particles are navigated to the targeted position under the influence of external magnetic force (EMF), which is applied in two different positions of the two-generation lung airways. A numerical particle tracing model is also developed to predict the magnetic drug targeting behavior in the lung. The numerical results reveal that nano-particle deposition efficiency (DE) in two different magnetic field position is different for various physical activities, which could be helpful for targeted drug delivery to a specific region of the lung after extensive clinical trials. This process will also be cost-effective and will minimize unwanted side effects due to systemic drug distribution in the lung.

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Magnetic nanodrug delivery in non-Newtonian blood flows

Fanelli

Kaouri

Phillips

et al. 2022

Microfluid Nanofluid

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With the goal of determining strategies to maximise drug delivery to a specific site in the body, we developed a mathematical model for the transport of drug nanocarriers (nanoparticles) in the bloodstream under the influence of an external magnetic field. Under the assumption of long (compared to the radius) blood vessels the Navier-Stokes equations are reduced, to a simpler model consistently with lubrication theory. Under these assumptions, analytical results are compared for Newtonian, power-law, Carreau and Ellis fluids, and these clearly demonstrate the importance of shear thinning effects when modelling blood flow. Incorporating nanoparticles and a magnetic field to the model we develop a numerical scheme and study the particle motion for different field strengths. We demonstrate the importance of the non-Newtonian behaviour: for the flow regimes investigated in this work, consistent with those in blood micro vessels, we find that the field strength needed to absorb a certain amount of particles in a non-Newtonian fluid has to be larger than the one needed in a Newtonian fluid. Specifically, for one case examined, a two times larger magnetic force had to be applied in the Ellis fluid than in the Newtonian fluid for the same number of particles to be absorbed through the vessel wall. Consequently, models based on a Newtonian fluid can drastically overestimate the effect of a magnetic field. Finally, we evaluate the particle concentration at the vessel wall and compute the evolution of the particle flux through the wall for different permeability values, as that is important when assessing the efficacy of drug delivery applications. The insights from our work bring us a step closer to successfully transferring magnetic nanoparticle drug delivery to the clinic.

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Numerical simulation of magnetic nano drug targeting in a patient-specific coeliac trunk

Cited by 23 publications

References 48 publications

Numerical simulation of magnetic nano drug targeting in patient-specific lower respiratory tract

Numerical simulation of magnetic nano drug targeting in patient-specific lower respiratory tract

Targeted Drug Delivery of Magnetic Nano-Particle in the Specific Lung Region

Magnetic nanodrug delivery in non-Newtonian blood flows

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