Numerical simulation of fluid flow and heat transfer in a trapezoidal microchannel with COMSOL multiphysics: A case study

Turgay, Metin Bilgehan; Yazıcıoğlu, Almıla G.

doi:10.1080/10407782.2017.1420302

Cited by 34 publications

(13 citation statements)

References 24 publications

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“…The air flow across the micro channel was simulated by COMSOL Multiphysics (Version 5.5, COMSOL Inc., Burlington, MA, United States) to calculate the pressure drop along the channel and chambers. The simulation was based on the coupling of the Navier-Stokes equation and the continuity equation in the stationary condition ( Turgay and Yazıcıoğlu, 2018 ; Chen et al, 2019 ). The incompressible laminar flow was used to obtain the solutions.…”

Section: Methodsmentioning

confidence: 99%

Recapitulation of Human Embryonic Heartbeat to Promote Differentiation of Hepatic Endoderm to Hepatoblasts

Yoshimoto

Minier

Yang

et al. 2020

Front. Bioeng. Biotechnol.

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Hepatic development requires multiple sequential physicochemical environmental changes in an embryo, and human pluripotent stem cells (hPSCs) allow for the elucidation of this embryonic developmental process. However, the current in vitro methods for hPSC-hepatic differentiation, which employ various biochemical substances, produce hPSC-derived hepatocytes with less functionality than primary hepatocytes, due to a lack of physical stimuli, such as heart beating. Here, we developed a microfluidic platform that recapitulates the beating of a human embryonic heart to improve the functionality of hepatoblasts derived from hepatic endoderm (HE) in vitro. This microfluidic platform facilitates the application of multiple mechanical stretching forces, to mimic heart beating, to cultured hepatic endoderm cells to identify the optimal stimuli. Results show that stimulated HE-derived hepatoblasts increased cytochrome P450 3A (CYP3A) metabolic activity, as well as the expression of hepatoblast functional markers (albumin, cytokeratin 19 and CYP3A7), compared to unstimulated hepatoblasts. This approach of hepatic differentiation from hPSCs with the application of mechanical stimuli will facilitate improved methods for studying human embryonic liver development, as well as accurate pharmacological testing with functional liver cells.

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Section: Methodsmentioning

confidence: 99%

Recapitulation of Human Embryonic Heartbeat to Promote Differentiation of Hepatic Endoderm to Hepatoblasts

Yoshimoto

Minier

Yang

et al. 2020

Front. Bioeng. Biotechnol.

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“…COMSOL is a leading numerical simulation software package capable of simulating a variety of physical processes. Its simulation data provided by this software are usually utilized as a standard [24][25][26]. Reflected wave time delays are associated with direct waves in the model, and the simulation.…”

Section: Simulating Channel Wave Multipath Transmission In a Coal Seammentioning

confidence: 99%

A Theoretical Investigation of Channel Wave Multipath Propagation in a Coal Seam

Guo

Zhang

et al. 2019

Mathematical Problems in Engineering

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This study investigates the mechanism of channel wave multipath propagation to determine features of a channel wave in a coal seam. For this purpose, deduction formulas were used for different time delays and propagation paths and, subsequently, a multipath fading channel wave pattern was built. MATLAB software was used to simulate the model. To this end, the characteristics of the coal seam and the surrounding rock were considered. The simulation results were compared with results obtained from the model contained in COMSOL software to verify the accuracy of the model. According to the results obtained from the simulation, the proposed model shows a good match with the COMSOL model, which is a common simulation comparison standard. In addition, the channel wave energy approximates to exponential decay at a constant distance from the source, and the multipath propagation considerably affects its energy attenuation. Furthermore, the multipath reflections’ travel time derivation is accomplished properly in the coal seam.

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“…COM-SOL Multiphysics offers the users various physics interfaces including fluid flow and heat transfer and multiple choices of element types, meshing procedures and solver types. 26) In this paper, the FEM software COMSOL Multiphysics is used to calculate the 3D transient temperature field of bearing rings in the vacuum furnace. And the veracity of the prediction temperature is verified by the experimental results.…”

Section: Introductionmentioning

confidence: 99%

Optimization of Heating Process for Bearing Rings in a Vacuum Furnace Based on Numerical Analysis

Liu¹,

Li²,

Wang³

et al. 2021

ISIJ Int.

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With the aid of a FEM software COMSOL Multiphysics the transient radiation heat transfer model has been established to simulate the vacuum heating process of M50NiL bearing rings. The heating curves obtained from the numerical model compare well with the experimental data. Based on the model, effects of heating process parameters on the radiative heat transfer in a vacuum furnace are investigated. The simulation results indicate that reducing heating rate or increasing preheating temperature can improve the temperature uniformity, thereby reducing the soaking time of bearing rings. Accordingly, an optimized heating process with high preheating temperature and low heating rate is proposed. The new process cuts the soaking time by a quarter and reduces the proportion of grade 3 and coarser grains from 12% to 2%.

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Numerical simulation of fluid flow and heat transfer in a trapezoidal microchannel with COMSOL multiphysics: A case study

Cited by 34 publications

References 24 publications

Recapitulation of Human Embryonic Heartbeat to Promote Differentiation of Hepatic Endoderm to Hepatoblasts

Recapitulation of Human Embryonic Heartbeat to Promote Differentiation of Hepatic Endoderm to Hepatoblasts

A Theoretical Investigation of Channel Wave Multipath Propagation in a Coal Seam

Optimization of Heating Process for Bearing Rings in a Vacuum Furnace Based on Numerical Analysis

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