The appropriate temperature is a critical factor for an enclosure with a stability guarantee. Therefore, in the prerequisite of vibration and Electro Magnetic Compatibility (EMC) being satisfied, how to make effective thermal design is what the research staff are generally concerned about. Firstly, a comprehensive description of the overall structure for a sealed enclosure is provided. Then the cooling plate is designed by using the method of theoretical calculation. At the same time, the temperature of the enclosure is analyzed by using Flow Simulation; the distribution of temperature field for the enclosure is obtained. Both classical heat transfer theory and a computational approach are used to verify the enclosure cooling performance. It turns out that applying the method of combining the theoretical calculation and simulation analysis cannot only improve the reliability of thermal analysis, but can also provide some valuable references to the research staff.