There are several factors that affect the hygiene in the surgical operating theatres. The HVAC airside system plays an important role to maintain the adequate hygiene level in the operating theatres. The present paper displays comparisons between different HVAC airside designs to assess their impact on the surgery staff and patient health and comfort. The present work utilizes a numerical modelling technique to predict local flow field characteristics, heat transfer and air distribution profiles. To reduce the infection possibilities of the surgery staff and patients, it should reduce the backward flow from the polluted zones towards the clean zones and the recirculated zones; also, the air infection by direct and indirect ways should be avoided. The present paper introduces suitable design of the HVAC airside system that is based on application of 'the centralized partially ceiling supply flow' with the two extract levels to ensure the hygiene of the occupancy of the operating theatres.