Numerical simulation of excitation-contraction coupling in a locus of the small bowel

Miftakhov, R.; Abdusheva, G. R.

doi:10.1007/s004220050257

Cited by 2 publications

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“…3) in comparison to the experimentally measured ones. To simulate the shape of excitations with better precision, advanced ionic models of smooth muscle, such as presented in Miftakhov & Abdusheva (1996), Miftakhov et al (1999) and Vigmond & Bardakjian (1998), would be required. An obstacle for the application of ionic models is the large number of equations involved, which makes it di$cult to simulate on available computers distributed systems with hundreds or thousands cells linked together.…”

mentioning

confidence: 99%

A Simple Nonlinear Model of Electrical Activity in the Intestine

Алиев

Richards

Wikswo

2000

Journal of Theoretical Biology

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confidence: 99%

A Simple Nonlinear Model of Electrical Activity in the Intestine

Алиев

Richards

Wikswo

2000

Journal of Theoretical Biology

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“…The stress (the force per unit cross‐sectional area) and strain (dimensionless change ratios) are useful parameters on both macro and micro scales because they are independent of the absolute size of the specimen. However, to link the relationship between the mechanical stimuli and the afferent discharge across the temporal and dimensional scales needs mechanical understanding at the cellular level (Prosser et al 2011) or sophisticated theoretical modelling (Miftakhov & Wingate, 1996; Miftakhov & Abdusheva, 1996). We have adopted the latter approach using a sophisticated strain softening protocol that was developed for time‐ and history‐dependent biomechanical studies (Johnson & Beatty, 1993; Emery et al 1997; Gregersen et al 1998).…”

Section: Discussionmentioning

confidence: 99%

Evidence for stress‐dependent mechanoreceptors linking intestinal biomechanics and sensory signal transduction

Gregersen¹,

Jiang

Liao

et al. 2012

Experimental Physiology

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New Findings r What is the central question of this study?Do intestinal mechanoreceptors respond primarily to stress (defined as force per unit cross sectional area) or strain (non-dimensional measure of deformation)? r What is the main finding and its importance?By using more physiological rates of filling (distension) combined with calcium channel blockade to limit active muscle tension, the adaptive properties of individual low and high threshold mechanosensitive afferents, have been examined. The slope of the stress-response relationship was not significantly different for the different populations of afferents nor for different rates of distension. These data therefore suggest that afferent activity is more closely related to stress rather than to strain. Sensory nerve endings are widely distributed throughout the body. Neither the nature of the mechanosensitive channels nor the principal mechanical stimulus for these receptors is known. Afferents supplying the gastrointestinal tract responding to distension and contraction are responsible for co-ordinated reflex control, feeding behaviour and sensations, including pain. Different populations of intestinal afferent fibres follow different pathways to the CNS, have different terminal fields and possess different thresholds for activation that may reflect the extent to which mechanical forces are distributed and dissipated by non-neural structures in the bowel wall. In this study, we have characterized the stimulus-response function of afferent fibres innervating the rat jejunum, correlating luminal distensions in the bowel wall with the firing frequency of mesenteric afferent nerve bundles. Combining video imaging with intraluminal pressure recordings and utilizing a strain softening protocol, we have determined whether mechanoreceptors respond primarily to stress or strain. Multiunit afferent recordings were separated using spike discrimination software into low-threshold (LT) and high-threshold (HT) single units. For multifibre afferent recordings and both LT and HT single units, we observed a linear relationship between circumferential stress and mesenteric afferent discharge that was independent of distension-induced tissue softening, with correlation coefficients >0.9. A fivefold change in the rate of applied distension did not significantly alter the magnitude of the afferent response and the linearity of the stress-dependent mechanotransduction in both multifibre preparations and the LT and HT afferent fibres (P > 0.2). Thus, the firing characteristics of intestinal mechanoreceptors are linearly associated with the input in terms of mechanical stress.

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Numerical simulation of excitation-contraction coupling in a locus of the small bowel

Cited by 2 publications

References 0 publications

A Simple Nonlinear Model of Electrical Activity in the Intestine

A Simple Nonlinear Model of Electrical Activity in the Intestine

Evidence for stress‐dependent mechanoreceptors linking intestinal biomechanics and sensory signal transduction

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