The research object in this paper is an industrial HTL gasifier in a plant. A three-dimensional model is built. The chemical percolation devolatilization (CPD) model is used to calculate the pyrolysis reaction. Considering the gas diffusion in the inner pores of the particle and the evolution of pore structure, the random pore model (RPM) was used to simulate the chemical reaction on the particle surface, and the gasification reaction kinetic parameter of char was measured by high-pressure thermogravimetry analysis. The slag model was constructed to describe the formation process and distribution of slag. Through the coupling of the above models, a simulation method that combines several submodels for the entrained flow gasifier is built, and the results from simulation are in good agreement with the industrial data. Furthermore, the effect of the uniformity of pulverized coal injection was analyzed by this method. The simulation results reflect that the asymmetric feed of coal will affect gas-solid mixing and reduce carbon conversion, and it leads to a higher local wall temperature and a lower ratio of crude slag to fine slag.