A modeling approach was utilized to achieve efficient operational conditions for Alizarin removal from synthetic wastewater in a T‐type micromixer. Besides experimental work, the neuro‐fuzzy system and artificial neural network techniques were utilized for this purpose. Input parameters were the pH, the initial Alizarin concentration in the feed, the extractant volume percentage in the organic phase, and the fluid flow rate. Based on the obtained results, both models have high precision. However, the accuracy of the neural network for estimating the extraction percentage is higher compared to that of the neuro‐fuzzy model. The optimal values of the operating parameters were determined by the genetic algorithm technique and the extraction percentage value was obtained as about 99.4 %.