Filtering is a stage in purification of liquids and is included in most technological processes; therefore, design and development of advanced filtering devices is required in order to increase the useful life aiming at energy and resource saving. The given work demonstrates that a hydrodynamic filter that combines filtering and centrifugal separation in a single implementation could become such a device. Numerical method was used to solve the system of hydrodynamic equations describing the medium flow in a hydrodynamic filter. Efficiency of solid particles separation by a centrifugal mechanism was calculated. As a result of the study, it was found out that motion trajectories of the particles up to 20 μm in size coincide with the liquid phase flow. Proposed integrated power effect on the flow under cleaning makes it possible to reduce the load on the filtering material and, as a result, to increase the filter service life. Satisfactory compliance between the experimental study results and the calculated values confirms adequacy of the mathematical model to the real flow pattern and possibility of its use in practical calculations of hydrodynamic and separation processes in a hydrodynamic filter. Using a hydrodynamic filter to remove solid contaminants from a liquid would provide a possibility to solve ecological problems that are acute for many industrial sectors.