Numerical simulation and experimental study of resonance characteristics of QCM-P devices operating in liquid and their application in biological detection

Wang, Pengtao; Su, Jun-Wei; Gong, Lin; Shen, Mengyan; Ruths, Marina; Sun, Hongwei

doi:10.1016/j.snb.2015.07.024

Cited by 23 publications

(16 citation statements)

References 47 publications

(53 reference statements)

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“…There has been a long history for quartz crystal microbalance (QCM) resonators to serve as a mass-frequency transducer, which vibrates in a thickness shear mode (TSM) mode. Own to its high sensitivity, stability, simple structure and low cost, QCMs has been widely applied in bio- or chemical sensing field [ 1 , 2 , 3 , 4 ]. Usually, the QCM resonator is composed of an ATcut quartz crystal piece and two metal film electrodes coated onto double surfaces of the quartz crystal chip.…”

Section: Introductionmentioning

confidence: 99%

Development of a Flow Injection Based High Frequency Dual Channel Quartz Crystal Microbalance

Liang

Zhang

Zhou

et al. 2017

Sensors

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When the quartz crystal microbalance (QCM) is used in liquid for adsorption or desorption monitoring based bio- or chemical sensing applications, the frequency shift is not only determined by the surface mass change, but also by the change of liquid characteristics, such as density and viscosity, which are greatly affected by the liquid environmental temperature. A monolithic dual-channel QCM is designed and fabricated by arranging two QCM resonators on one single chip for cancelling the fluctuation induced by environmental factors. In actual applications, one QCM works as a specific sensor by modifying with functional membranes and the other acts as a reference, only measuring the liquid property. The dual-channel QCM is designed with an inverted-mesa structure, aiming to realize a high frequency miniaturized chip and suppress the frequency interference between the neighbored QCM resonators. The key problem of dual-channel QCMs is the interference between two channels, which is influenced by the distance of adjacent resonators. The diameter of the reference electrode has been designed into several values in order to find the optimal parameter. Experimental results demonstrated that the two QCMs could vibrate individually and the output frequency stability and drift can be greatly improved with the aid of the reference QCM.

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Section: Introductionmentioning

confidence: 99%

Development of a Flow Injection Based High Frequency Dual Channel Quartz Crystal Microbalance

Liang

Zhang

Zhou

et al. 2017

Sensors

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“…which couple the mechanical effect as governed by Newton's law and the electrical effect as determined by Gauss law, see references [11][12][13]. Where T ij is the stress matrix, S jk is the strain matrix, D i is the electric displacement vector, E j is the applied electric field vector and subscripts i, j, k, l = x, y, z.…”

Section: Mathematical Methodsmentioning

confidence: 99%

Determining biosensing modes in SH-SAW device using 3D finite element analysis

Brookes

Bufacchi

Kondoh

et al. 2016

Sensors and Actuators B: Chemical

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a b s t r a c tSurface acoustic wave (SAW) sensors are electromechanical devices that exploit the piezoelectric effect to induce elastic (acoustic) waves which are sensitive to small perturbations: for example specific binding and recognition of disease biomarkers. Shear horizontal surface acoustic waves (SH-SAWs) are particularly suited to biosample analysis as the wave is not completely radiated and lost into the liquid medium (e.g., blood, saliva) as is the case, for example, in a device implementing Rayleigh waves. Here, using 3D finite element analysis (FEA) the nature of waves launched on a particular quartz device is investigated with respect to the cut of the quartz, the addition of gold guiding layers, and the addition of other linear elastic materials of contrasting acoustic properties. It is demonstrated that 3D FEA analysis showing the device's frequency shift with added guiding layer height reveals a proportional relationship in agreement with the Sauerbrey equation from perturbation theory. It is directly shown, given certain device parameters and a gold guiding layer, that shear horizontally polarized waves are launched on the surface with a dominant mode frequency around 250 MHz. This would be an appropriate biosensing mode in Point of Care (POC) testing for the particular properties of certain disease biomarkers delivered via a liquid medium.

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“…Peschel et al [39] carried out experiments on coupled resonance using a QCM device with small dust grain, glass fibre, and a Lycopodium spore to study the contact stiffness and aging of adhesive contacts with the device. Wang et al [40] reported an experimental and numerical analysis of the QCM resonator with PMMA micropillars designed on its surface for biological detection in liquid media. The device with a similar configuration was also employed for humidity sensing, and at the critical height of micropillars, the device provided maximum mass sensitivity [41].…”

Section: Coupled Resonancementioning

confidence: 99%

ZnO nanorod‐based Love wave delay line for high mass sensitivity: a finite element analysis

Trivedi

Nemade

2019

IET Science, Measurement & Technology

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Numerical simulation and experimental study of resonance characteristics of QCM-P devices operating in liquid and their application in biological detection

Cited by 23 publications

References 47 publications

Development of a Flow Injection Based High Frequency Dual Channel Quartz Crystal Microbalance

Development of a Flow Injection Based High Frequency Dual Channel Quartz Crystal Microbalance

Determining biosensing modes in SH-SAW device using 3D finite element analysis

ZnO nanorod‐based Love wave delay line for high mass sensitivity: a finite element analysis

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