Numerical sex chromosome aberrations in juvenile angiofibromas: Genetic evidence for an androgen-dependent tumor?

Juvenile Nasopharyngeal Angiofibroma Extending into the Oral Cavity: A Rare Entity

“…Role of chromosomal alteration are also detected in JNA. Gains at chromosomes 4, 6, 8, and X and losses on chromosomes 17, 22, and Y are the most frequent chromosomal abnormalities detected [4][5][6][7][8]. Schick also described AURKA gene (20q13.2) with a possible role in chromosomal and genetic instability in JA [6].…”

Investigation of the prognostic value of the apoptotic marker p53 gene and vascular endothelial growth factor in evaluating the clinical course of nasopharyngeal angiofibroma

“…Опухоль не только оттесняет, но и разрушает близлежа-щие структуры, вызывая деструкцию кости, прорастает в орбиту, полость черепа, в результате чего развивают-ся тяжелые внутричерепные осложнения, нарушаются функции жизненно важных органов. Еще одним по-следствием данного заболевания является спонтанное носовое кровотечение, которое приводит иногда к ле-тальному исходу [1][2][3][4][5].…”

Juvenile Nasopharyngeal Angiofibroma- Five Years Study in a Tertiary Hospital of Kerala

“…Recurrence is well recorded in these tumours, although they are histologically benign. 5 Recurrence has been reported to be 20% -42%, although it may be higher with intracranial extension. The mainstay of treatment is surgical excision.…”

“…This could explain why the prevalence is higher in males. 5 Due to its locally aggressive nature, results in extension of the tumour expanding from the nose to fill the antrum later spreading to infra-temporal fossa, which in turn expands the cheek and at times invades the ethmoid and produce a frog face deformity. Diagnosis is usually made based on a careful clinical history and a detailed physical examination to describe the signs and symptoms, the morphology and epidemiology and the radiological findings.…”