Numerical relationship between cells with radiation-induced chromosome aberrations and cells lethally injured by radiation

Abstract

The numerical relationship between radiation-induced chromosome aberrations in human G0 lymphocytes and reproductive lethality of human bone-marrow lymphocytes is analysed within a large LET interval. The comparison is based upon the evaluation of the coefficient a of the linear component of the corresponding dose-effect-relation for the frequency of cells without aberrations and for the frequency of surviving cells respectively. The good correlation between these coefficients over a large LET interval supports the hypothesis that structural chromosome aberrations and reproductive cell death both result from the same gross chromatin damage.

An analysis of the distribution and dose response of chromosome aberrations in human lymphocytes after in vitro exposure to137Cesium gamma radiation

“…2) is typical of curves from cell survival experiments [21,34] and thus presents a good correlation between chromosome damage and cell death. The 'normal' cell curve may also be thought of as a dose-response curve and can be plotted as in Fig.…”