During pile installation, the stresses and void ratios in the surrounding soils change significantly, creating large displacements, large strains, soil disturbance and the development of excess porewater pressures. The surrounding disturbed soil tends to regain its strength with time due to both consolidation and thixotropic effects. In this paper, the pile installation process and the subsequent consolidation, thixotropy and load tests conducted at different times after end of driving (EOD) were modeled for the test piles at Bayou Laccassine Bridge site, Louisiana. In the FE model, the pile was considered as an elastic material and the anisotropic modified cam-clay model (AMCCM) was used to describe the behavior of the surrounding clayey soils. Pile installation was modeled by applying prescribed radial and vertical displacements on the nodes at the soil-pile interface (volumetric cavity explanation), followed by vertical deformation to activate the soil-pile interface friction and to simulate static load tests. The thixotropic effect was incorporated by applying a time-dependent reduction parameter, β, which affects both the interface friction and the material properties. The results from the FE numerical simulation included the development of excess porewater pressure during pile installation and its dissipation with time, the increase in effective lateral stress at the pile-soil interface, changes on stress state of surrounding soil, and the setup attributed to both the soil consolidation and thixotropy at different times. The FE results are compared with the measured values obtained from the fullscale instrumented pile load tests, which showed good agreement between measured and FE predicted results.