Numerical prediction of flow fields in baffled stirred vessels: A comparison of alternative modelling approaches

Brucato, Alberto; Ciofalo, Michele; Grisafi, F.; Micale, Giorgio Domenico Maria

doi:10.1016/s0009-2509(98)00149-3

Cited by 273 publications

(192 citation statements)

References 0 publications

Supporting

Mentioning

177

Contrasting

Unclassified

Order By: Relevance

“…1) allowed imposition of rotation motion on domains C and B, while A was left stationary. This is the normal practice for modelling rotational machinery to take into account the periodic motion caused by the presence of impeller blades and baffles (Brucato et al 1998). The relative motion between the interfaces was treated using the multiple frame of reference protocol with its two variants for steady state simulations (the frozen rotor scheme) and sliding mesh for transient ones (Aubin et al 2004).…”

Section: Geometry and Computational Gridmentioning

confidence: 99%

“…Successful application of CFD to biotechnological systems range, for instance, from simulations of bioreactors to separation devices (Brucato et al 1998;Castilho 2001;Medronho et al 2005). A successful example was the use of CFD to predict the flow field inside a bioreactor (Brucato et al 1998). The authors were able to reasonably reproduce different velocity profiles obtained by laser doppler anemometry.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

CFD simulation of an internal spin-filter: evidence of lateral migration and exchange flow through the mesh

et al. 2009

View full text Add to dashboard Cite

In the present work Computational Fluid Dynamics (CFD) was used to study the flow field and particle dynamics in an internal spin-filter (SF) bioreactor system. Evidence of a radial exchange flow through the filter mesh was detected, with a magnitude up to 130-fold higher than the perfusion flow, thus significantly contributing to radial drag. The exchange flow magnitude was significantly influenced by the filter rotation rate, but not by the perfusion flow, within the ranges evaluated. Previous reports had only given indirect evidences of this exchange flow phenomenon in spin-filters, but the current simulations were able to quantify and explain it. Flow pattern inside the spinfilter bioreactor resembled a typical Taylor-Couette flow, with vortices being formed in the annular gap and eventually penetrating the internal volume of the filter, thus being the probable reason for the significant exchange flow observed. The simulations also showed that cells become depleted in the vicinity of the mesh due to lateral particle migration. Cell concentration near the filter was approximately 50% of the bulk concentration, explaining why cell separation achieved in SFs is not solely due to size exclusion. The results presented indicate the power of CFD techniques to study and better understand spin-filter systems, aiming at the establishment of effective design, operation and scale-up criteria.

show abstract

Section: Geometry and Computational Gridmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

CFD simulation of an internal spin-filter: evidence of lateral migration and exchange flow through the mesh

et al. 2009

View full text Add to dashboard Cite

show abstract

“…The procedure involves steady state approximation of essential periodic flow and correction for the relative motion and azimuthal averaging are required before using flow field at the interface as boundary condition for solution of flow field in the other domain. A variant of MRF approach is the inner-outer approach in which the inner and outer regions are partially overlapping (Brucato et al, 1998).…”

Section: Cfd Modeling Of Mechanically Agitated Baffled Tanksmentioning

confidence: 99%

CFD modeling of pilot-scale pump-mixer: Single-phase head and power characteristics

Singh

Mahajani

Shenoy

et al. 2007

Chemical Engineering Science

View full text Add to dashboard Cite

The present work involves single-phase computational fluid dynamics (CFD) simulations of continuous flow pump-mixer employing topshrouded Rushton turbines with trapezoidal blades. Baffle-impeller interaction has been modeled using sliding mesh and multiple reference frame approaches. Standard k-model has been used for turbulence modeling. Several CFD runs representing different combinations of geometric and process parameters have been carried out. Results of CFD simulations have been used to find out two macroscopic performance parameters of pump-mixer-power consumption and head generated by the impeller. The simulation results have been compared with the experimental data obtained on a pilot-scale setup. Good agreement between CFD predictions and experimental results is observed. In most cases, sliding mesh approach is found to perform better than multiple reference frame approach. Details from CFD simulations have been used to have an insight into the pumping action of the impeller.

show abstract

“…The modelling of stirred tanks has been long established to characterise rotational flow [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. For the majority of numerical studies of stirred tanks the liquid surface is not considered to deform with agitation (i.e.…”

Section: Introductionmentioning

confidence: 99%

“…The use of the free slip surface is validated by the conditions in the tank that reduce the likelihood of vortex formation (i.e. baffles [8-9, 13, 15, 18], location, size and shape of the impeller and the tank flow regime [6][7][8][9][11][12][13][14][15][16][17][18][19][20][21]). …”

Section: Introductionmentioning

confidence: 99%

Modelling vortex formation in an unbaffled stirred tank reactors

Cartland-Glover¹,

Fitzpatrick²

2007

Chemical Engineering Journal

View full text Add to dashboard Cite

Numerical prediction of flow fields in baffled stirred vessels: A comparison of alternative modelling approaches

Cited by 273 publications

References 0 publications

CFD simulation of an internal spin-filter: evidence of lateral migration and exchange flow through the mesh

CFD simulation of an internal spin-filter: evidence of lateral migration and exchange flow through the mesh

CFD modeling of pilot-scale pump-mixer: Single-phase head and power characteristics

Modelling vortex formation in an unbaffled stirred tank reactors

Contact Info

Product

Resources

About