An intelligent optimization technique has been presented to enhance the multiple structural performance of PA6-20CF carbon fiber-reinforced polymer (CFRP) plastic injection molding (PIM) products. This approach integrates a deep neural network (DNN), Non-dominated Sorting Genetic Algorithm II (NSGA-II), and Monte Carlo simulation (MCS), collectively referred to as the DNN-GA-MCS strategy. The main objective is to ascertain complex process parameters while elucidating the intrinsic relationships between processing methods and material properties. To realize this, a numerical study on the PIM structural performance of an automotive front engine hood panel was conducted, considering fiber orientation tensor (FOT), warpage, and equivalent plastic strain (PEEQ). The mold temperature, melt temperature, packing pressure, packing time, injection time, cooling temperature, and cooling time were employed as design variables. Subsequently, multiple objective optimizations of the molding process parameters were employed by GA. The utilization of Z-score normalization metrics provided a robust framework for evaluating the comprehensive objective function. The numerical target response in PIM is extremely intricate, but the stability offered by the DNN-GA-MCS strategy ensures precision for accurate results. The enhancement effect of global and local multi-objectives on the molded polymer–metal hybrid (PMH) front hood panel was verified, and the numerical results showed that this strategy can quickly and accurately select the optimal process parameter settings. Compared with the training set mean value, the objectives were increased by 8.63%, 6.61%, and 9.75%, respectively. Compared to the full AA 5083 hood panel scenario, our design reduces weight by 16.67%, and achievements of 92.54%, 93.75%, and 106.85% were obtained in lateral, longitudinal, and torsional strain energy, respectively. In summary, our proposed methodology demonstrates considerable potential in improving the, highlighting its significant impact on the optimization of structural performance.