Numerical modeling of microbubble backscatter to optimize ultrasound particle image velocimetry imaging: initial studies

Mukdadi, Osama M.; Kim, Hyoung-Bum; Hertzberg, Jean; Shandas, Robin

doi:10.1016/j.ultras.2004.02.021

Cited by 34 publications

(26 citation statements)

References 35 publications

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“…Contrast echocardiography (56,57) can provide important information regarding the 2-dimensional features of LV intracavitary flow during the different phases of cardiac cycle ( Fig. 8A and B) (58).…”

Section: Intracavitary Flow Sequencementioning

confidence: 99%

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Left Ventricular Form and Function Revisited: Applied Translational Science to Cardiovascular Ultrasound Imaging

Sengupta

Krishnamoorthy

Kořínek

et al. 2007

Journal of the American Society of Echocardiography

276

196

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Tissue Doppler imaging (TDI) and TDI-derived strain imaging are robust physiologic tools used for the noninvasive assessment of regional myocardial function. Due to high temporal and spatial resolution, regional function can be assessed for each phase of the cardiac cycle and within the transmural layers of the myocardial wall. Newer techniques that measure myocardial motion by speckle tracking in grayscale images have overcome the angle dependence of TDI strain, allowing for measurement of 2-dimensional strain and cardiac rotation. TDI, TDI strain, and speckle tracking may provide unique information that deciphers the deformation sequence of complexly oriented myofibers in the left ventricular wall. The data are, however, limited. This review examines the structure and function of the left ventricle relative to the potential clinical application of TDI and speckle tracking in assessing the global mechanical sequence of the left ventricle in vivo.The spiral arrangement of muscle fibers in the heart is reminiscent of spiral and vortex patterns in nature, ranging from small organelles and whirlpools to hurricanes and rotational patterns of the galaxies (1-5). Vortex patterns link two fundamental forms of motion that work in close balance: an inner, rapidly descending swirl and an outer, less rapid, ascending rotation (4) ( Fig. 1 A-C). These counterdirectional movements of a vortex produce suction and expulsion forces that have been exploited for designing energy efficient propellers and turbines (6). Likewise, experimental and mathematical modeling of the clockwise and counterclockwise spiral loops of myofibers in the left ventricle (LV) has shown that counterdirectional geometry provides an efficient distribution of regional stresses and strains (7). Conversely, altered ventricular geometry resulting from cardiac remodeling, regional myocardial dysfunction, or asynchronous conduction distort the efficiency of the loading and expulsion dynamics (8,9). In this review, we associate the LV myofiber architecture to the spatiotemporal sequence of regional deformations occurring during normal cardiac contraction and relaxation. We further elucidate experimental observations, which explore the application of tissue Doppler imaging (TDI) and 2-dimensional ultrasound speckle tracking for delineation of the synchronous mechanical shortening and lengthening sequences of the human LV.Address reprint requests to Marek Belohlavek, Division of Cardiovascular Diseases, Mayo Clinic, 13400 East Shea Boulevard Scottsdale, AZ 85259, E-mail address for author named in reprint line: Belohlavek.marek@mayo.edu Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect th...

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Section: Intracavitary Flow Sequencementioning

confidence: 99%

“…8A and B) (58). Contrast bubbles can be tracked in time and space for visualization of flow vectors in 2-, 3-or higher-dimensional images (56,57,59). …”

mentioning

confidence: 99%

Left Ventricular Form and Function Revisited: Applied Translational Science to Cardiovascular Ultrasound Imaging

Sengupta

Krishnamoorthy

Kořínek

et al. 2007

Journal of the American Society of Echocardiography

276

196

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“…A lipid shell enhance the lifetime of the bubble, which would otherwise dissolve in seconds (Jong et al 2009). Their acoustic impedance leads to strong scattering, which is enhanced by non-linear oscillations of the bubble shape (Frinking et al 2000;Mukdadi et al 2004). UCAs are commercially available through various companies and various types/brands have been used in UIV experiments.…”

Section: Seeding Materialsmentioning

confidence: 99%

Ultrasound Imaging Velocimetry: a review

Poelma

2016

Exp Fluids

104

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“…Therefore several microbubble-based contrast agents have been developed and are applied clinically to enhance the echogenicity of vasculature and organ-specific regions [267][268][269][270][271][272]. These microbubbles composed of surfactant, protein, and/or polymer shells containing gas cores, for example air, perfluorocarbons, or nitrogen should have an optimum size of 2-3 μm for common imaging practice [273]. Contrast agents for ultrasound imaging echogenic liposomes, [274][275][276] perfluorocarbon droplets, [277] and other materials such as gold particles, which have a density and compressibility substantially different from that of blood and tissue.…”

Section: Ultrasound (Us)mentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville³

2016

Nano Online

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The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in synthesis protocol and characterization of these materials whereas toxicological issues are sometimes incomplete. Nanoparticle-based contrast agents tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of 2 imaging modalities. Multimodal nanoparticles (NPs) are much more efficient than conventional molecular-scale contrast agents. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides specific applications for classical imaging, (MRI, PET, CT, US, PAI) are also mentioned less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA).Perspectives on multimodal theranostic NPs and their potential for clinical advances are also mentioned.

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Numerical modeling of microbubble backscatter to optimize ultrasound particle image velocimetry imaging: initial studies

Cited by 34 publications

References 35 publications

Left Ventricular Form and Function Revisited: Applied Translational Science to Cardiovascular Ultrasound Imaging

Left Ventricular Form and Function Revisited: Applied Translational Science to Cardiovascular Ultrasound Imaging

Ultrasound Imaging Velocimetry: a review

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

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