Numerical investigation on the structural characteristics of multiple RBCs in a stenotic microcapillary under plasma-alcohol solution

Abstract

Alcohol significantly affects blood rheology and influences the mechanical behavior of red blood cells (RBCs). Previous studies indicate that plasma-RBC and multiple RBC interaction are important indicators for atherosclerosis progression. Therefore, multiphysics interactions under highly viscous conditions of alcohol consumption and stenosis structure must be investigated. A 2D microcapillary model, wherein multiple RBCs float through a stenotic structure, was established to investigate the effect of alcohol on cell motion and deformability under various flow conditions. Results show that the deformed cells inside the stenosis increase flow resistance and increase plasma velocity gradient in the pre and post stenotic regions. Moreover, the effect of the initial RBC position is important describing the RBC deformation pattern. The structural properties of RBCs may be significantly affected when the stenosis path is filled by cells that increase flow resistance.