Numerical investigation of three-dimensional bubble dynamics

Afanasiev, Konstantin; Grigorieva, I. V.

doi:10.1007/s10665-005-9006-1

Cited by 7 publications

(2 citation statements)

References 18 publications

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“…Image theory and boundary integral methods are utilized. Prosperetti, 1990a, b, 1993;Takahira, 1997;Yuan and Prosperetti, 1997;Zeff et al, 2000;Brujan et al, 2001;Brujan et al, 2002;Brujan et al, 2004;Fong et al, 2006;Cui et al, 2006;Krasovitski and Kimmel, 2004;Nyborg, 1958;Sato et al, 1994;Afanasiev and Grigorieva, 2006;Blake et al, 1999;Bremond et al, 2006) l: within a tube During insonation, ultrasound contrast microbubbles oscillate within blood vessels. To study bubble oscillation within a small vessel, the vessel can be simplified as a rigid or compliant tube.…”

Section: Assumptionsmentioning

confidence: 99%

Ultrasound contrast microbubbles in imaging and therapy: physical principles and engineering

Qin¹,

Caskey²,

Ferrara³

2009

Phys. Med. Biol.

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Microbubble contrast agents and the associated imaging systems have developed over the past twenty-five years, originating with manually-agitated fluids introduced for intra-coronary injection. Over this period, stabilizing shells and low diffusivity gas materials have been incorporated in microbubbles, extending stability in vitro and in vivo. Simultaneously, the interaction of these small gas bubbles with ultrasonic waves has been extensively studied, resulting in models for oscillation and increasingly sophisticated imaging strategies. Early studies recognized that echoes from microbubbles contained frequencies that are multiples of the microbubble resonance frequency. Although individual microbubble contrast agents cannot be resolved-given that their diameter is on the order of microns-nonlinear echoes from these agents are used to map regions of perfused tissue and to estimate the local microvascular flow rate. Such strategies overcome a fundamental limitation of previous ultrasound blood flow strategies; the previous Doppler-based strategies are insensitive to capillary flow. Further, the insonation of resonant bubbles results in interesting physical phenomena that have been widely studied for use in drug and gene delivery. Ultrasound pressure can enhance gas diffusion, rapidly fragment the agent into a set of smaller bubbles or displace the microbubble to a blood vessel wall. Insonation of a microbubble can also produce liquid jets and local shear stress that alter biological membranes and facilitate transport. In this review, we focus on the physical aspects of these agents, exploring microbubble imaging modes, models for microbubble oscillation and the interaction of the microbubble with the endothelium.

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Section: Assumptionsmentioning

confidence: 99%

Ultrasound contrast microbubbles in imaging and therapy: physical principles and engineering

Qin¹,

Caskey²,

Ferrara³

2009

Phys. Med. Biol.

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“…Special considerations are needed in this approach when the time dependent solution reaches to a state in which the bubble splitting occurs or a hole is created in the bubble as a result of the jet penetration. Also the bubble surface triangulation in the 3D simulations is a challenge (9,10) . The potential flow assumption is no longer acceptable when the viscous effects become important (3) .…”

Section: Introductionmentioning

confidence: 99%

Intensification of the Near Wall Collapsing Bubble Induced Jet Using an Opposite Secondary Wall

Teymouri

Ahmadi

2008

JFST

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Effects of an opposite secondary wall for intensification of the liquid jet that is formed through the near wall bubble collapse were numerically investigated. The axisymmetric form of the Navier-Stokes equations was solved to predict the flow conditions inside and outside the bubble. The volume of fluid approach was incorporated to capture the bubble surface. Putting an opposite secondary wall in the same distance from the bubble center as the primary wall distance, necking of the bubble was observed after the bubble reaches to its maximum volume. After the bubble splitting occurred, formation of two separating jets toward the primary and secondary walls was observed. It was notable that putting the secondary wall leads to the formation of the jet with a higher velocity magnitude. Also the jet velocity magnitude increased with increasing the secondary wall distance from the bubble center up to a certain limit. These analyses were performed for several initial inside to outside pressure ratios of the bubble. The results of the present simulations can be implemented to improve the tasks applying the near wall bubble collapse, like the collapsing bubble induced micro-pump.

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Interaction of Underwater Blasts and Submerged Structures

Abrate

2012

Dynamic Failure of Composite and Sandwich Structures

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Numerical investigation of three-dimensional bubble dynamics

Cited by 7 publications

References 18 publications

Ultrasound contrast microbubbles in imaging and therapy: physical principles and engineering

Ultrasound contrast microbubbles in imaging and therapy: physical principles and engineering

Intensification of the Near Wall Collapsing Bubble Induced Jet Using an Opposite Secondary Wall

Interaction of Underwater Blasts and Submerged Structures

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