Numerical Investigation of the Mixing Efficiency in Square-Wave Passive Micromixers for Microfluidic Device Applications

Ionescu, Viorel

doi:10.1109/eurocon52738.2021.9535570

Cited by 1 publication

(1 citation statement)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among the planar passive micromixers, serpentine micromixers − have considerably been investigated, stemming from requiring small footprints to benefit from the associated effects properly. The comprehensive studies on the planar serpentine micromixers have concluded that the square-wave micromixer provides the best mixing compared to other types. − In the planar-square-wave-micromixer-based studies, two concepts can generally be exploited: (I) increasing the total mixing length of the micromixer via the strategies like adding to the number of mixing units, ,, using sinusoidal paths instead of straight paths, or increasing the structural dimensions of the base micromixer, , and (II) altering the width of the micromixer’s channels in a simple or complicated manner . However, the first concept causes the micromixer to need additional build materials, which raises its fabrication cost and increases the buildup pressure, making its integration within lab-on-a-chip systems challenging.…”

Section: Introductionmentioning

confidence: 99%

A Novel Strategy for Square-Wave Micromixers: A Survey of RBC Lysis for Further Biological Analysis

Hazeri,

Abouei Mehrizi,

Mohseni

et al. 2023

Ind. Eng. Chem. Res.

View full text Add to dashboard Cite

Most biorelated applications require homogeneous mixing, necessitating innovative approaches to design high-efficiency micromixers. In this study, for the first time, we have changed the straight structure of a base square-wave micromixer to include regularpolygon-designed mixing units coupled with convergent−divergent channels. The aim was to show that the designed mixing units can enhance mixing at low Reynolds (Re) numbers. Importantly, within the optimization process, the mixing volume and mixing length of the micromixers were kept intact. In this respect, the required numerical evaluations were conducted to obtain the optimized micromixers at Re = 0.1 and 2, where the mixing index for the base micromixer increased from 0.9187 to 0.9944 and from 0.1600 to 0.4043, respectively. Finally, to prove that the optimized micromixers possess a better practical performance than the base micromixer, RBC lysis, as a vital preprocessing step of many biological experiments, was compared at Re = 0.1 and 2 for the base and optimized micromixers.

show abstract