Numerical investigation of the influence of pattern topology on the mechanical behavior of PEGDA hydrogels

Jin, Tao; Stanciulescu, Ilinca

doi:10.1016/j.actbio.2016.10.041

Cited by 18 publications

(15 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By these models, the elastic modulus of scaffolds was predicted with a good agreement with the measured ones [8,22]. FEM-based models can also be used to represent the change of mechanical properties of scaffolds with time due to the scaffold degradation [23] and the mechanical behavior of Poly(ethylene glycol) diacrylate hydrogels with complex geometric shapes [6]. It has been illustrated that FEM is a powerful tool to model the scaffold mechanical properties.…”

Section: Appl Sci 2018 8 X For Peer Review 2 Of 13mentioning

confidence: 97%

“…Tissue scaffolds can be fabricated by either conventional or modern techniques. Conventional methods, like electrospinning, are limited for the fabrication of 3D scaffolds with interconnected pores [4,5] and in some cases, organic solvents have to be used, thus being detrimental for cellular proliferation/differentiation [6]. Nowadays, additive manufacturing (AM) techniques have drawn considerable attention since they allow fabrication of scaffolds layer-by-layer [7], and thus open a new door to create scaffolds with a complex 3D microstructure and a controllable pore shape and size [8].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Modeling of the Mechanical Behavior of 3D Bioplotted Scaffolds Considering the Penetration in Interlocked Strands

et al. 2018

View full text Add to dashboard Cite

Three-dimensional (3D) bioplotting has been widely used to print hydrogel scaffolds for tissue engineering applications. One issue involved in 3D bioplotting is to achieve the scaffold structure with the desired mechanical properties. To overcome this issue, various numerical methods have been developed to predict the mechanical properties of scaffolds, but limited by the imperfect representation of one key feature of scaffolds fabricated by 3D bioplotting, i.e., the penetration or fusion of strands in one layer into the previous layer. This paper presents our study on the development of a novel numerical model to predict the elastic modulus (one important index of mechanical properties) of 3D bioplotted scaffolds considering the aforementioned strand penetration. For this, the finite element method was used for the model development, while medium-viscosity alginate was selected for scaffold fabrication by the 3D bioplotting technique. The elastic modulus of the bioplotted scaffolds was characterized using mechanical testing and results were compared with those predicted from the developed model, demonstrating a strong congruity between them. Once validated, the developed model was also used to investigate the effect of other geometrical features on the mechanical behavior of bioplotted scaffolds. Our results show that the penetration, pore size, and number of printed layers have significant effects on the elastic modulus of bioplotted scaffolds; and also suggest that the developed model can be used as a powerful tool to modulate the mechanical behavior of bioplotted scaffolds.

show abstract

Section: Appl Sci 2018 8 X For Peer Review 2 Of 13mentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Modeling of the Mechanical Behavior of 3D Bioplotted Scaffolds Considering the Penetration in Interlocked Strands

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Jin et al recognized the importance of patterning PEGDA hydrogels in such a way that the anisotropic properties of native leaflets could be preserved. This group simulated different patterns of scaffolds created by photolithographic patterning in order to guide the design of PEGDA hydrogels to advance the structure of TEHVs . The incorporation of anisotropic properties into PEG hydrogel scaffolds is currently being improved to better mimic native valve leaflets to develop more functional TEHVs.…”

Section: Application Of Biomaterials To Heart Valve Tissue Engineeringmentioning

confidence: 99%

Developing a Clinically Relevant Tissue Engineered Heart Valve—A Review of Current Approaches

Nachlas

Davis

2017

Adv Healthcare Materials

View full text Add to dashboard Cite

Tissue engineered heart valves (TEHVs) have the potential to address the shortcomings of current implants through the combination of cells and bioactive biomaterials that promote growth and proper mechanical function in physiological conditions. The ideal TEHV should be anti-thrombogenic, biocompatible, durable, and resistant to calcification, and should exhibit a physiological hemodynamic profile. In addition, TEHVs may possess the capability to integrate and grow with somatic growth, eliminating the need for multiple surgeries children must undergo. Thus, this review assesses clinically available heart valve prostheses, outlines the design criteria for developing a heart valve, and evaluates three types of biomaterials (decellularized, natural, and synthetic) for tissue engineering heart valves. While significant progress has been made in biomaterials and fabrication techniques, a viable tissue engineered heart valve has yet to be translated into a clinical product. Thus, current strategies and future perspectives are also discussed to facilitate the development of new approaches and considerations for heart valve tissue engineering.

show abstract

“…Furthermore, the printing parameters greatly impact the mechanical and dissolution properties of the produced samples. For example, pattern ratio, orientation and waviness of models affected the mechanical behavior of the printed hydrogels [19], whereas the specific surface area of models modulated the drug-release behavior of printed tablets [20]. Considering the various morphological and functional requirements of implants and physiological channels, further studies on the effect of printing parameters and model design are important.…”

Section: Introductionmentioning

confidence: 99%

Printability of External and Internal Structures Based on Digital Light Processing 3D Printing Technique

et al. 2020

View full text Add to dashboard Cite

The high printing efficiency and easy availability of desktop digital light processing (DLP) printers have made DLP 3D printing a promising technique with increasingly broad application prospects, particularly in personalized medicine. The objective of this study was to fabricate and evaluate medical samples with external and internal structures using the DLP technique. The influence of different additives and printing parameters on the printability and functionality of this technique was thoroughly evaluated. It was observed that the printability and mechanical properties of external structures were affected by the poly(ethylene glycol) diacrylate (PEGDA) concentration, plasticizers, layer height, and exposure time. The optimal printing solutions for 3D external and internal structures were 100% PEGDA and 75% PEGDA with 0.25 mg/mL tartrazine, respectively. And the optimal layer height for 3D external and internal structures were 0.02 mm and 0.05 mm, respectively. The optimal sample with external structures had an adequate drug-loading ability, acceptable sustained-release characteristics, and satisfactory biomechanical properties. In contrast, the printability of internal structures was affected by the photoabsorber, PEGDA concentration, layer height, and exposure time. The optimal samples with internal structures had good morphology, integrity and perfusion behavior. The present study showed that the DLP printing technique was capable of fabricating implants for drug delivery and physiological channels for in vivo evaluation.

show abstract

Numerical investigation of the influence of pattern topology on the mechanical behavior of PEGDA hydrogels

Cited by 18 publications

References 52 publications

Modeling of the Mechanical Behavior of 3D Bioplotted Scaffolds Considering the Penetration in Interlocked Strands

Modeling of the Mechanical Behavior of 3D Bioplotted Scaffolds Considering the Penetration in Interlocked Strands

Developing a Clinically Relevant Tissue Engineered Heart Valve—A Review of Current Approaches

Printability of External and Internal Structures Based on Digital Light Processing 3D Printing Technique

Contact Info

Product

Resources

About