Numerical investigation of renal artery hemodynamics based on the physiological response to renal artery stenosis

Andayesh, M; Shahidian, Azadeh; Ghassemi, Majid

doi:10.1016/j.bbe.2020.08.006

Cited by 17 publications

(7 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was meshed using FLUENT 19 software, wherein the outer surface of the entire model consisted of octahedral elements and the interior, hexahedral elements; hence, the name Poly-Hexcore mesh. It is an application of mosaic technology in meshing, which results in 20-50% reduction in element count, thus speeding up the simulation process [48]. Prior to the transient simulation, grid independency tests were carried out in both the healthy and stenosed Artery-30 models.…”

Section: Discussionmentioning

confidence: 99%

Numerical Analysis on A Non-Critical Stenosis in Renal Artery

Hegde

Shenoy

Barboza

et al. 2021

ARFMTS

View full text Add to dashboard Cite

The increase in cardiovascular diseases worldwide has resulted in higher death rate of people globally; the primary reason being atherosclerosis. A better understanding of this condition can be achieved through the application of numerical methods to understand the haemodynamics. The present study aims to investigate the effects of renal artery angulation on the flow characteristics in a non-critically stenosed artery compared to that of a normal artery in order to understand better, the reasons for causes and progression of renal artery stenosis. Abdominal aorta-renal artery models ranging from 30° to 90° angulations were generated from computerized tomography-angiogram slices, post which they were subjected to cleanup and defeaturing. Haemodynamic parameters such as velocity, pressure and time-averaged wall shear stress were evaluated at early systole, peak systole and peak diastole for the different artery models. Extensive amounts of flow recirculation were observed in normal renal arteries with higher bifurcating angles, whereas it was not the case in stenosed arteries where flow acceleration was seen for the duration of the cardiac cycle. Evaluation of static pressure encountered a similar trend where an increase in angulation saw a decrease in pressure for normal arteries which contradicted with stenosed artery results. Analysis of shear stress saw very similar trends in normal and stenosed arteries, with lower angulation profiles experiencing higher values of shear stress at the Ostia. In the cases of arteries of higher angulation with a non-critical stenosis, the possibility of worsening of stenosis into an opprobrious stage remains a concern.

show abstract

Section: Discussionmentioning

confidence: 99%

Numerical Analysis on A Non-Critical Stenosis in Renal Artery

Hegde

Shenoy

Barboza

et al. 2021

ARFMTS

View full text Add to dashboard Cite

show abstract

“…Since the peak Reynolds number is lower than the critical Reynolds number, the inlet flow is assumed to be subcritical during the cycle, so a laminar flow model is used. This usually occurs in large arteries due to the low mean flow velocity 3 , 13 , 48 , 49 .…”

Section: Methodsmentioning

confidence: 99%

The effect of beta-blockers on hemodynamic parameters in patient-specific blood flow simulations of type-B aortic dissection: a virtual study

Abazari

Rafieianzab

Soltani

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Aortic dissection (AD) is one of the fatal and complex conditions. Since there is a lack of a specific treatment guideline for type-B AD, a better understanding of patient-specific hemodynamics and therapy outcomes can potentially control the progression of the disease and aid in the clinical decision-making process. In this work, a patient-specific geometry of type-B AD is reconstructed from computed tomography images, and a numerical simulation using personalised computational fluid dynamics (CFD) with three-element Windkessel model boundary condition at each outlet is implemented. According to the physiological response of beta-blockers to the reduction of left ventricular contractions, three case studies with different heart rates are created. Several hemodynamic features, including time-averaged wall shear stress (TAWSS), highly oscillatory, low magnitude shear (HOLMES), and flow pattern are investigated and compared between each case. Results show that decreasing TAWSS, which is caused by the reduction of the velocity gradient, prevents vessel wall at entry tear from rupture. Additionally, with the increase in HOLMES value at distal false lumen, calcification and plaque formation in the moderate and regular-heart rate cases are successfully controlled. This work demonstrates how CFD methods with non-invasive hemodynamic metrics can be developed to predict the hemodynamic changes before medication or other invasive operations. These consequences can be a powerful framework for clinicians and surgical communities to improve their diagnostic and pre-procedural planning.

show abstract

“…where and represent the density and pressure, respectively. The blood flow was assumed to be laminar [4,28,29]. Reynolds number in the AA was approximately 1900.…”

Section: Computational Fluid Dynamicsmentioning

confidence: 99%

The Effect of Beta-Blockers on Hemodynamic Parameters in Patient-Specific Blood Flow Simulations of Type-B Aortic Dissection: An Virtual Study

Abazari

Rafieianzab

Soltani

et al. 2021

Preprint

View full text Add to dashboard Cite

Type-B aortic dissection (AD) is one of the greatest complex and fatal conditions with co-occurring disorders, challenging to treat. The initial treatment for patients presenting with AD is medical intervention to stabilize the condition. In the present study, a patient-specific geometry of type-B AD is generated from computed tomography images, and a three-element Windkessel lumped parameter model is implemented at the outlets to realistic boundary conditions. According to the physiological response of the antihypertensive drugs in the reduction of aortic blood flow and heart rate, three case studies with different heart rates have been created. Hemodynamic distributions including wall shear stress indicators, velocity and pressure are investigated and compared in each model. Results show that there is a considerable reduction in pressure furthermore, time-averaged wall shear stress (TAWSS) values decreased by 25% and 30%, respectively. Main goal is to critically analysis the use of biomechanical and computational simulation tools to measure hemodynamic parameters in the absence and presence of antihypertensive drugs. It would be of significant use to clinicians to improve diagnostic and treatment planning.

show abstract

Numerical investigation of renal artery hemodynamics based on the physiological response to renal artery stenosis

Cited by 17 publications

References 39 publications

Numerical Analysis on A Non-Critical Stenosis in Renal Artery

Numerical Analysis on A Non-Critical Stenosis in Renal Artery

The effect of beta-blockers on hemodynamic parameters in patient-specific blood flow simulations of type-B aortic dissection: a virtual study

The Effect of Beta-Blockers on Hemodynamic Parameters in Patient-Specific Blood Flow Simulations of Type-B Aortic Dissection: An Virtual Study

Contact Info

Product

Resources

About