Numerical investigation of partially liquefied vitreous dynamics as two-phase viscoelastic-Newtonian fluid flow in a planar cavity due to oscillatory motion

Mathematical Model of Macromolecular Drug Transport in a Partially Liquefied Vitreous Humor

“…Without any liquefaction, the eye motion causes little in the way of fluid transport in the vitreous. However, with the presence of liquid pockets, the oscillatory motion of the eyes can create circulatory currents [19,20]. Rotational oscillatory motions can lead to streaming, which, compared to pressure-driven transport, can be significant within the liquid portion [19].…”

“…The vitreous is a viscoelastic structure that with liquefaction can experience distortion due to saccadic motion [20]. This again is a complex piece of the comprehensive model that will be implemented as the model developed further.…”

The role of eye movements in the process of silicone oil emulsification after vitreoretinal surgery

“…7 Thus, a major factor influencing SO emulsification is represented by eye movement as shear stresses at the SO-aqueous interface generated during eye rotations (such as saccadic motions and REMs), which play a key role in destabilising the interface. [8][9][10][11] Fluid dynamics in the vitreous chamber produced by eye rotations has been studied with numerical models, [12][13][14][15][16][17][18] experimental approaches, [19][20][21] and in-vivo measurements, 22,23 demonstrating that the flow field induced by eye rotations has a complicated three dimensional structure. Recent experimental studies investigated the motion of 3 was not certified by peer review) is the author/funder.…”

“…7 Thus, a major factor influencing SO emulsification is represented by eye movement as shear stresses at the SO-aqueous interface generated during eye rotations (such as saccadic motions and REMs), which play a key role in destabilising the interface. [8][9][10][11] Fluid dynamics in the vitreous chamber produced by eye rotations has been studied with numerical models, [12][13][14][15][16][17][18] experimental approaches, [19][20][21] and in-vivo measurements, 22,23 demonstrating that the flow field induced by eye rotations has a complicated three dimensional structure. Recent experimental studies investigated the motion of SO partially filling a model of the vitreous chamber, 8,9 the shape of the interface SO-aqueous solution in the eye, 24 the dynamics induced by eye rotations 25 and the mechanisms relating shear flow generated by eye rotations with the breakdown of the SO-aqueous interface, 26 demonstrating the need of understanding the behavior of vitreous substitutes and the shear force as a factor influencing emulsification.…”

Heat Removal from a Human Eye for Different Environmental Conditions - a Cfd Study Using a Full-Scale Manikin

“…Their research explores the impact of aging on various eye parameters, including heat transfer, aqueous humor ow, intraocular pressure, and drug distribution across different eye regions and orientations. Bayat et al [15]- [17] studied partial vitreous liquefaction (PVL) ow dynamics as a twophase viscoelastic-Newtonian uid in 2D and 3D human eye models. Rahman et al [18] studied the anatomical and physiological changes in the human eye as it ages.…”