Numerical Investigation of Bone Tumor Hyperthermia Treatment Using Magnetic Scaffolds

Abstract

This works claims to define, via numerical simulations, magnetic field parameters to perform an effective in situ bone tumor hyperthermia treatment using magnetic scaffolds. A Cole-Cole model to describe the frequency response of the magnetic susceptibility of nanoparticles embedded in novel magnetic biomaterials is explored. The heating phenomena is investigated considering both the ischemic and inflamed state of the fracture gap at the bone/implants interface. Both Osteosarcoma and Fibrosarcoma tumors are analyzed. Magnetic hydroxyapatite and poly-ε-caprolactone scaffolds are investigated. From the thermal analysis, it is found that the fracture behaves as a resistance to heat conduction, therefore strength and frequency of external magnetic field has to be tuned to perform the treatment taking the fracture status into account. Moreover, numerical experiments indicate that low perfused Fibrosarcoma can be treated using moderate-strength field, whereas more intense external fields are required to treat strongly vascularized Osteosarcoma without damaging healthy bone tissue. Magnetic hydroxyapatite stands out to be the most performant and versatile material to treat both tumors. These simulations can be regarded as a starting point to analyze possible clinical use of magnetic scaffolds for in situ bone hyperthermia.

Nanomagnetic Actuation of Hybrid Stents for Hyperthermia Treatment of Hollow Organ Tumors

“…With this model, the temperature increase of magnetic scaffolds activated in an AMF was explained based on a smooth decrease of MNP susceptibility for increasing frequency. This differs from the expectations for dispersed MNP, which exhibit a peak susceptibility as described with the Debye model [ 41 , 44 ]. A similar change of the susceptibility was also observed for MNP embedded in hydrogel [ 45 ].…”

Mathematical Modeling Of Magnetic Scaffolds For Targeted Drug Delivery And Bone Repair

“…The magnetic moment of the MNP is µ mnp , in JT -1 and φ is the volumetric fraction of nanoparticles in the biomaterial matrix. For each scaffold the MNPs are assumed to be monodisperse in size and to be homogeneously distributed in the prosthetic implant [24], [26]. The MagS of interest are reported in Tab.…”

Abnormal absorption of subcritical water posts in microwave heating

“…In this model, the TM plane wave normally incidents from the free space into the water post, whose radius and height are a and infinite, respectively. Usually, the relative complex permittivity of water can be described by the Debye model or the Cole‐Cole model . Here, due to the fact that the Debye model can predict the permittivity properties of subcritical water well in experiments, so we fit the Debye model with temperature …”

“…Usually, the relative complex permittivity of water can be described by the Debye model or the Cole-Cole model. [28][29][30][31] Here, due to the fact that the Debye model can predict the permittivity properties of subcritical water well in experiments, so we fit the Debye model with temperature. 31…”