The optimal topology and its performance in dynamic loading situations result in discontinue function corresponding to the input factors such as volume fraction, thickness, material property, and loading conditions. In a realist scenario, the performance prediction becomes erroneous and challenging for the components under dynamic loading conditions with uncertainties. The conventional closed-form deterministic approaches are complicated for these problems. Here, a method is presented to establish the relative influence and function relationship of the input factors with the performance values, including controllable and non-controllable uncertainties. The design of experiment approach is used to apply full factorial design with Taguchi’s orthogonal array; performances of the optimal topologies are considered responses. The non-uniform topology generation method is applied based on the deflection threshold value to generate topologies for dynamic conditions. A dynamic model of the manipulator-link is developed to apply boundary conditions and provide performance values: compliance, deflection, Stress, and energy consumption values. Statistical techniques such as the analysis-of-mean (ANOM), analysis-of-variance (ANOVA), signal-to-noise-ratio (SNR), and mean performance values are employed to observe the significance of input factors and generate equivalent preformation relation. From ANOM and ANOVA, all input parameters show mutual interaction; force is observed as the most significant factor. From SNR values, experimental combination number 9,9,6,1 is observed as the most robust for compliance (21.13), deflection (43.93), Stress (−16.64), and energy consumption (12.05). Similarly, at the same combinations, the mean performance values are minimum and coefficient of determination (R2) percentages of the model are 94.64%, 96.93%, 73.69%, and 95.14%.