Currently, the frame structures with special-shaped concrete-filled steel tubular columns have been widely used in super high-rise buildings. Those structural members can be used to improve architectural space. To investigate the seismic behavior of spatial composite frames that were constructed by connecting steel beams to L-shaped concrete-filled steel tubular (CFST) columns, a finite element analysis (FEA) model using commercial finite element software ABAQUS was proposed to simulate the behavior of the composite spatial frames under a static axial load on columns and a fully-reversed lateral cyclic load applied to frames in this paper. Several nonlinear factors, including geometry and material properties, were taken into account in this FEA model. Four spatial specimens were designed, and the corresponding experiments were conducted to verify the proposed FEA model. Each testing specimen was two-story structure consisting of eight single span steel beams and four L-shaped CFST columns. The test results showed that the proposed FEA model in this paper could evaluate the behavior of the composite spatial frames accurately. Based on the results of the nonlinear analysis, the stress developing progress of columns is investigated. The load transferring mechanism and failure mechanism are also determined. The results are discussed and conclusions about the behavior of those spatial frame structures are presented. the literatures. Herrera et al. [25] used the finite element analysis program, named as DRAIN-2DX, to establish a full-scale model of a four-story and five-bay frame made of wide flange H-shaped beams connecting to square CFST columns. Dasgupta et al. [26] carried out the test for a three-story and three-bay planar frame with CFST column connecting to steel beam. Liu and Li [27] conducted a test to demonstrate that the yield load, ultimate load-carrying capacity, and ductility of the frame that was filled with masonry wall were greatly improved, as compared to those in the pure frame structure. Han [28] built a finite element analysis (FEA) to study the behavior of the composite frame, and the results obtained from the FEA model were validated against the test results. Li et al. [29] investigated the seismic performance of CFST frame structure under the constant axial load and cyclic horizontal load. Wang et al. [30] analyzed the mechanism of composite frames with steel beams connecting to concrete-filled square steel tubular columns by using FEA modeling and proposed the simplified hysteretic lateral load-displacement models. Wang et al. [31] established the nonlinear finite element model of squared CFST frame to study the influence of the slenderness ratio. Hu et al. [32] and Park et al.[33] developed a design methodology for moment resisting frame structures with tubular CFST columns and conducted a nonlinear pushover analysis on the numerical frame models. Wang [34,35] conducted an experimental study and nonlinear finite element analysis to study the seismic behavior of concrete-filled square steel tu...