Numerical and experimental studies on pulsatile flow in aneurysms arising laterally from a curved parent vessel at various angles

Liou, Tong‐Miin; Li, Yi‐Chen; Juan, Wei-Cheng

doi:10.1016/j.jbiomech.2006.05.024

Cited by 38 publications

(35 citation statements)

References 19 publications

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“…Although most aneurysm rupture-risk morphological analyses 8,10 such as AR 12 and nonsphericity 10 consider the aneurysm dome as a separate entity detaching it from the neck up, our analysis of IA incorporates the relation of the aneurysm dome to the parent vessel. This spatial relationship has been shown to be an important determinant of flow patterns inside the aneurysm dome 19,23 and may influence rupture risk, consistent with our idealized CFD model findings. A recent study by Dhar et al 27 evaluated the angle of inclination between the aneurysm dome and its neck plane; although significantly different in their ruptured subset, the angle of inclination between the aneurysm dome and its neck plane was not found to be an independent discriminant in a multivariate analysis.…”

Section: Baharoglu Et Al Inflow-angle In Ruptured Cerebral Aneurysmssupporting

confidence: 87%

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Aneurysm Inflow-Angle as a Discriminant for Rupture in Sidewall Cerebral Aneurysms

Baharoglu

Schirmer

Hoit

et al. 2010

Stroke

167

131

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Background and Purpose-The ability to discriminate between ruptured and unruptured cerebral aneurysms on a morphological basis may be useful in clinical risk stratification. The objective was to evaluate the importance of inflow-angle (IA), the angle separating parent vessel and aneurysm dome main axes. Methods-IA, maximal dimension, height-width ratio, and dome-neck aspect ratio were evaluated in sidewall-type aneurysms with respect to rupture status in a cohort of 116 aneurysms in 102 patients. Computational fluid dynamic analysis was performed in an idealized model with variational analysis of the effect of IA on intra-aneurysmal hemodynamics. Results-Univariate analysis identified IA as significantly more obtuse in the ruptured subset (124.9°Ϯ26.5°versus105.8°Ϯ18.5°, Pϭ0.0001); similarly, maximal dimension, height-width ratio, and dome-neck aspect ratio were significantly greater in the ruptured subset; multivariate logistic regression identified only IA (Pϭ0.0158) and height-width ratio (Pϭ0.0017), but not maximal dimension or dome-neck aspect ratio, as independent discriminants of rupture status. Computational fluid dynamic analysis showed increasing IA leading to deeper migration of the flow recirculation zone into the aneurysm with higher peak flow velocities and a greater transmission of kinetic energy into the distal portion of the dome. Increasing IA resulted in higher inflow velocity and greater wall shear stress magnitude and spatial gradients in both the inflow zone and dome. Conclusions-Inflow-angle is a significant discriminant of rupture status in sidewall-type aneurysms and is associated with higher energy transmission to the dome. These results support inclusion of IA in future prospective aneurysm rupture risk assessment trials. (Stroke.

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Section: Baharoglu Et Al Inflow-angle In Ruptured Cerebral Aneurysmssupporting

confidence: 87%

“…22 A second model was constructed on the outer bend of a circular curved geometry with varying IA in plane with parent vessel curvature. 23 High-resolution polyhedral meshes with prismatic boundary layer enrichment were generated with Star-CCMϩ …”

Section: Aneurysm Model and Computational Methodsmentioning

confidence: 99%

Aneurysm Inflow-Angle as a Discriminant for Rupture in Sidewall Cerebral Aneurysms

Baharoglu

Schirmer

Hoit

et al. 2010

Stroke

167

131

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“…in [2,3,4,5]) have been performed to study the WSS induced by blood flow and its relationship with aneurysm genesis. The problem with the CFD approach is that a huge computational cost is required for full 3D analysis of a large vasculature.…”

Section: Discussionmentioning

confidence: 99%

“…in [2,3,4,5]. The techniques used include non-invasive in vivo MR imaging [3], in vitro phantom experiments [4], and three-dimensional (3D) computational fluid dynamics (CFD) modelling [2], or a combination of these techniques [5].…”

Section: Introductionmentioning

confidence: 99%

A Hybrid 1D and 3D Approach to Hemodynamics Modelling for a Patient-Specific Cerebral Vasculature and Aneurysm

Sands

Schmid

et al. 2009

Medical Image Computing and Computer-Assisted Intervention – MICCAI 2009

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Abstract. In this paper we present a hybrid 1D/3D approach to haemodynamics modelling in a patient-specific cerebral vasculature and aneurysm. The geometric model is constructed from a 3D CTA image. A reduced form of the governing equations for blood flow is coupled with an empirical wall equation and applied to the arterial tree. The equation system is solved using a MacCormack finite difference scheme and the results are used as the boundary conditions for a 3D flow solver. The computed wall shear stress (WSS) agrees with published data.

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“…The definition of inlet velocity with Reynolds number of 200 is in the range of intracranial flow presented in MR imaging of Isoda et al [32]. Liou et al [33] suggested that the characteristics of aneurysm inflow and outflow area under the steady-state condition are consistent with those under the pulsatile condition, except for small differences. And Newtonian-fluid assumption does not greatly affect the global aneurysmal flow obtained with the non-Newtonian model, confirming previous studies [34]- [36].…”

Section: Discussionmentioning

confidence: 99%

Combinational Optimization of Strut Placement for Intracranial Stent Using a Realistic Aneurysm

Anzai¹,

Chopard²,

Ohta³

2014

JFCMV

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Stent insertion for cerebral aneurysm has been studied using ideal and realistic aneurysms in recent years. Stent insertion aims at reducing the flow in an aneurysm. To minimize the average velocity in an aneurysm, we applied optimization to the strut position in a realistic aneurysm based on computational fluid dynamics. The result shows the effect on velocity reduction of strut placement in the inflow area.

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Numerical and experimental studies on pulsatile flow in aneurysms arising laterally from a curved parent vessel at various angles

Cited by 38 publications

References 19 publications

Aneurysm Inflow-Angle as a Discriminant for Rupture in Sidewall Cerebral Aneurysms

Aneurysm Inflow-Angle as a Discriminant for Rupture in Sidewall Cerebral Aneurysms

A Hybrid 1D and 3D Approach to Hemodynamics Modelling for a Patient-Specific Cerebral Vasculature and Aneurysm

Combinational Optimization of Strut Placement for Intracranial Stent Using a Realistic Aneurysm

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