Numerical and experimental studies of mechanisms underlying the effect of pulsed broadband terahertz radiation on nerve cells

Duka, M. V.; Dvoretskaya, L N; Babelkin, N S; Khodzitskiĭ, M. K.; Chivilikhin, S A; Smolyanskaya, O. A.

doi:10.1070/qe2014v044n08abeh015486

Cited by 29 publications

(7 citation statements)

References 19 publications

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“…Is well known that the THz pulsed TDS is traditionally used for the detection and identification of explosive and illicit drug [1][2][3][4][5][6][7][8][9][10]. Moreover, it is currently considered to be a new powerful tool for application in the chemical sciences and molecular structure investigations [11][12][13][14], nondestructive inspections [15][16][17][18], thickness measurements [19,20], art investigations [21,22], pharmaceutical and biomedical applications [23][24][25][26], and food quality control [27][28][29]. In [30], a comprehensive review of the history and state of the art of the GaN-based devices for THz applications is provided.…”

Section: Literature Review and Introductionmentioning

confidence: 99%

Spurious Absorption Frequency Appearance Due to Frequency Conversion Processes in Pulsed THz TDS Problems

Trofimov

Wang

Qiu

et al. 2020

Sensors

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The appearance of the spurious absorption frequencies caused by the frequency conversion process at the broadband THz pulse propagation in a medium is theoretically and experimentally discussed. The spurious absorption frequencies appear due to both the frequency doubling and generation of waves with sum or difference frequency. Such generation might occur because of the nonlinear response of a medium or its non-instantaneous response. This phenomenon is confirmed by the results of a few physical experiments provided with the THz CW signals and broadband THz pulses that are transmitted through the ordinary or dangerous substances. A high correlation between the time-dependent spectral intensities for the basic frequency and generated frequencies is demonstrated while using the computer simulation results. This feature of the frequency conversion might be used for the detection and identification of a substance.

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Section: Literature Review and Introductionmentioning

confidence: 99%

Spurious Absorption Frequency Appearance Due to Frequency Conversion Processes in Pulsed THz TDS Problems

Trofimov

Wang

Qiu

et al. 2020

Sensors

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“…The nervous system is built from two broad categories of cells, neurons and glial cells. For living neurons, it has been proved that the THz wave could induce the changes of membranes potential (MP) [10] and the growth of neurites of sensory ganglia [11]. Additionally, the direct visualization of neuron swelling induced by temperature change was measured by ionic contrast THz (ICT) imaging [12].…”

Section: Introductionmentioning

confidence: 99%

Study of the dielectric characteristics of living glial-like cells using terahertz ATR spectroscopy

Wang

Jiang

et al. 2019

Biomed. Opt. Express

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The attenuated total reflection spectroscopy system with the Si container attached on the prism has been demonstrated as an efficient technique to obtain the dielectric properties of living cells in the THz range. We proposed a method to determine the dielectric responses of living cells based on the combination of the single-interface and two-interface ATR models without cell thickness. The experimental results for living glial-like cells (PC12, SVG P12 and HMO6) showed the dielectric responses in the THz region were related significantly to cell number, intracellular fluid, and cell structure. Moreover, the glioma cells (C6 and U87) exhibited different dielectric properties compared with the glial-like cells, which could be one reason for the glioma tissue diagnosis using THz wave.

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“…Terahertz (THz) spectroscopy application for medical purposes is expanding rapidly due to its safety feature, growing number of global population and development of novel diagnostic technologies [1]- [2][3][4] [5]. Development of any THz biomedical devices requires phantoms for device testing and calibration.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Water-free Biotissue-mimicking Phantoms in Terahertz Frequency Range

Zhang

Khodzitsky

Demchenko

et al. 2018

2018 43rd International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)

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PVC-based water-free phantoms with silicon and zinc oxide nanoparticles were fabricated for mimicking biotissues in the terahertz frequency range. Terahertz time-domain spectroscopy (TDS) was used to obtain the refractive indices and absorption coefficients of the phantoms. Their optical properties were compared with those of real biotissues from published data. The results show that the phantoms are able to mimic human skin, paraffin-embedded glioma and paraffin-embedded healthy brain tissue by their optical properties. The refractive index of the phantoms can be controlled by changing the concentration of the nanoparticles.

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Numerical and experimental studies of mechanisms underlying the effect of pulsed broadband terahertz radiation on nerve cells

Cited by 29 publications

References 19 publications

Spurious Absorption Frequency Appearance Due to Frequency Conversion Processes in Pulsed THz TDS Problems

Spurious Absorption Frequency Appearance Due to Frequency Conversion Processes in Pulsed THz TDS Problems

Study of the dielectric characteristics of living glial-like cells using terahertz ATR spectroscopy

Investigation of Water-free Biotissue-mimicking Phantoms in Terahertz Frequency Range

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