An appropriate diffuser following an impeller is critical to realize a high efficiency and a wide operating range for a centrifugal compressor stage. The purpose of this study is to investigate the effect of different types of vaned diffusers on a large mass flow coefficient centrifugal compressor stage performance under different operating conditions and to reveal the loss mechanisms in the vaned diffusers. Five vaned diffusers are studied. Flow fields and vortices in a conventional diffuser and a rib diffuser are first examined. Then, vortices and flow fields in three different tandem diffusers are analyzed in detail. For the three tandem diffusers, only circumferential position of first row vanes relative to the second row vanes is different. Results show that the stage with the conventional diffuser possesses the shortest operating range. The rib diffuser has less loss due to the weaker tip leakage vortex, while its static pressure recovery coefficient is lower, and the loss in the following return part is higher. Comparison results between the three tandem diffusers imply that when the trailing edge of the first row vane is close to the pressure surface of the second row vane, the stage with the tandem diffuser has a better performance. This is ascribed to the interaction of the tip leakage vortex and suction surface vortex, which decreases the total loss, especially reduces the loss induced by the suction surface vortex. When the trailing edge of the first row vanes is close to the suction surface of the second row vane, the loss is increased since the leading edge vortex has a large strength and surrounds the suction surface vortex. Therefore, the reasonable interaction of vortices in a tandem diffuser can bring a high performance of the centrifugal compressor.