Numerical and experimental analysis of influence of granule microstructure on its compression breakage

Dosta, Maksym; Dale, Steven; Antonyuk, Sergiy; Wassgren, Carl; Heinrich, Stefan; Litster, James D.

doi:10.1016/j.powtec.2016.05.005

Cited by 64 publications

(45 citation statements)

References 33 publications

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“…We have numerically simulated the YSZ hollow sphere PhGs presented in Figure h. The structure realizations of randomly packed PhGs of YSZ hollow spheres with 64% packing density were obtained by the packing generator MUSEN . The periodic boundary condition was used in the packing algorithm to avoid packing density variations at the edges of the packed volume.…”

mentioning

confidence: 99%

YSZ Hollow Sphere Photonic Glasses: Tailoring Optical Properties for Highly Saturated Non‐Iridescent Structural Coloration

Häntsch

Shang

Petrov

et al. 2019

Advanced Optical Materials

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adom.201900428. Structural ColorationThe natural world provides a vast number of inspirational sources for the design and development of new materials with outstanding properties. The feather barbs of the plum-throated cotinga is one out of many examples for demonstrating the way by which nature generates intense colors based on the mechanism of structural coloration and without the need for pigments. [1,2] Structural colors are the result of spectrally selective light scattering caused by nanostructures whereas the color

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mentioning

confidence: 99%

YSZ Hollow Sphere Photonic Glasses: Tailoring Optical Properties for Highly Saturated Non‐Iridescent Structural Coloration

Häntsch

Shang

Petrov

et al. 2019

Advanced Optical Materials

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“…In addition, the elasticity property of HPMC‐E3 enhanced the structural integrity of the pellets and lowered the friability (Li et al, ). This would fulfill the requirement of the pellets structural rigidity in fluidized bed granulation (Dosta et al, ).…”

Section: Resultsmentioning

confidence: 97%

Modified‐release oral pellets for duodenum delivery of doxycycline hyclate

Huang

et al. 2019

Drug Development Research

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To minimize the gastric and esophageal injury effect, a system to deliver doxycycline hyclate (DOXY) to the duodenum area is needed. DOXY‐containing modified‐release oral pellets (DMOP) coated with hydroxypropyl methylcellulose phthalate HP‐55 (HPMCP HP‐55) and hydroxypropyl methylcellulose E15 (HPMC E15) appear to be a reasonable choice. This coating layer dissolves at pH 5.5, which is the pH of the duodenum, but not at a gastric pH (1.2). The formulation and preparation of DMOP were optimized, and a scale‐up test was performed. The results showed that the production reproducibility was acceptable, and the quality of DMOP well met the standards of Chinese Pharmacopeia (Ch.P, 2015 edition). Notably, the accumulated DOXY release was lower than 50% at pH 1.2 (20 min) and higher than 85% at pH 5.5, which met the USP40‐NF35 standard for DOXY modified‐release formulations. Moreover, the storage stability of DMOP with different packages was investigated by stress testing, accelerated and long‐term testings. The stability of DMOP was maintained up to 12 months, in terms of DOXY content and in vitro release behavior. The results seem to suggest that DMOP could be a promising duodenum delivery system.

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“…The BPM is an extension of the DEM, where each two primary particles can be connected by solid or liquid bonds [11][12][13][14]. This allows to create spherical or irregular-shaped objects as aggregates consisting of primary particles connected with bonds [13].…”

Section: Bonded-particle Model (Bpm)mentioning

confidence: 99%

Numerical investigation of compaction of deformable particles with bonded-particle model

2017

Self Cite

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In this contribution, a novel approach developed for the microscale modelling of particles which undergo large deformations is presented. The proposed method is based on the bonded-particle model (BPM) and multi-stage strategy to adjust material and model parameters. By the BPM, modelled objects are represented as agglomerates which consist of smaller ideally spherical particles and are connected with cylindrical solid bonds. Each bond is considered as a separate object and in each time step the forces and moments acting in them are calculated. The developed approach has been applied to simulate the compaction of elastomeric rubber particles as single particles or in a random packing. To describe the complex mechanical behaviour of the particles, the solid bonds were modelled as ideally elastic beams. The functional parameters of solid bonds as well as material parameters of bonds and primary particles were estimated based on the experimental data for rubber spheres. Obtained results for acting force and for particle deformations during uniaxial compression are in good agreement with experimental data at higher strains.

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Numerical and experimental analysis of influence of granule microstructure on its compression breakage

Cited by 64 publications

References 33 publications

YSZ Hollow Sphere Photonic Glasses: Tailoring Optical Properties for Highly Saturated Non‐Iridescent Structural Coloration

YSZ Hollow Sphere Photonic Glasses: Tailoring Optical Properties for Highly Saturated Non‐Iridescent Structural Coloration

Modified‐release oral pellets for duodenum delivery of doxycycline hyclate

Numerical investigation of compaction of deformable particles with bonded-particle model

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