Numerical analysis of pulsatile blood flow and vessel wall mechanics in different degrees of stenoses

Li, M.X.; Beech-Brandt, J.J.; John, L.R.; Hoskins, Peter; Easson, W. J.

doi:10.1016/j.jbiomech.2007.06.023

Cited by 136 publications

(79 citation statements)

References 32 publications

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“…From the Table 4 result it is clear that our result was in good agreement with both the experimentally measured data by Li et al [33] and in vivo measured data by Di Mario et al [32], and Siebes et al [34]. At the peak flow rate, the Reynolds numbers at the narrowest points in 28%, 53%, and 54% stenoses (stenosis ST2, ST1, and ST3) are about 865, 1141, and 1118, respectively.…”

Section: Flow Separation and Secondary Flowsupporting

confidence: 90%

Clinical important hemodynamic characteristics for serial stenosed coronary artery

Bernad¹,

Bernad²,

Totorean³

et al. 2015

Int. J. DNE

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Effects of serial stenosis on coronary hemodynamics are investigated in the human right coronary artery (RCA) by blood flow analysis. The 3D reconstruction of the geometry of the stenosed coronary artery uses the multislice computerized tomography serial images method. Results of the numerical analysis present the hemodynamic characteristics of the serial stenosed coronary artery throughout the flow separation, pressure drop and wall shear stress. The pressure loss associated with recirculation region created in the vicinity of each constriction was found to be large. In two stenoses the corresponding pressure gradients are around 30 mmHg and correspond to the stenosis with fractional flow reserve-FFR < 0.7 (value associated to the severe stenosis). Distal to the stenosis, flow is associated with fluctuations in the wall shear stress and vorticity. Both FFR and CFD analysis help identify intermediate lesions that require intervention and reduce unnecessary procedures with potential complications.

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Section: Flow Separation and Secondary Flowsupporting

confidence: 90%

Clinical important hemodynamic characteristics for serial stenosed coronary artery

Bernad¹,

Bernad²,

Totorean³

et al. 2015

Int. J. DNE

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“…This will be presented in the results section. The average reported viscosity of the blood (µ bl,av = 0.004 Pa·s [Chatziprodromou et al 2007;Li et al 2007]) is situated in between that of water (µ water = 0.001 Pa·s) and that of the BSIR (µ BSIR = 0.0085 Pa·s [Bloomfield et al 1998]). For an average strain rate under the given loading conditions of about 10 s −1 for the BVs (depending on their length and loading time), the stresses developed due to viscosity are very small (typically of the order of 0.01 Pa) compared to other stresses developed by the harder materials of the RVE under the same mechanical loads.…”

Section: Materials Descriptionmentioning

confidence: 97%

An asymptotic method for the prediction of the anisotropic effective elastic properties of the cortical vein: superior sagittal sinus junction embedded within a homogenized cell element

Rahman

George

Baumgartner

et al. 2012

J. Mech. Mater. Struct.

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Bridging veins (BVs) are frequently damaged in traumatic brain injury due to brain-skull relative motion. These veins, connected to the superior sagittal sinus (SSS), are prone to rupture upon head impact giving rise to an acute subdural hematoma (ASDH). We modeled the biomechanical characteristics of ASDH to study the behavior of the SSS-BVs compound with its surrounding medium. The almost periodic distribution of the BVs along the SSS allowed the use of the homogenization method based on asymptotic expansion to calculate the effective elastic properties of the brain-skull interface region. The representative volume element (RVE) under study is an anisotropic equivalent medium with homogenized elastic properties, accounting for the variations of each constituent's mechanical properties. It includes the sinus, the BVs and blood, and the surrounding cerebrospinal fluid and tissue. The results show large variations in the RVE anisotropic properties depending on each constituent of the BV and, to a certain extent, on the variability of the surrounding constituents' mechanical properties.

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“…The shear rate varies over a range of 1-1200 s −1 over a cardiac cycle in human arteries (Li et al, 2007). So, blood behaves as non-Newtonian fluid during some instants of the cardiac cycle.…”

Section: Non-newtonian Viscosity Modelsmentioning

confidence: 99%

Pulsatile Non-Newtonian Fluid Flows in a Model Aneurysm with Oscillating Wall

2017

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This research presents a numerical simulation of an unsteady two-dimensional channel flow of Newtonian and some non-Newtonian fluids using the finite-volume method. The walls of the geometry oscillate sinusoidally with time. We have used the Cartesian curvilinear coordinates to handle complex geometries, i.e., arterial stents and bulges and the governing Navier-Stokes equations have been modified accordingly. Physiological pulsatile flow has been used at the inlet to characterize four different non-Newtonian models, i.e., the (i) Carreau, (ii) Cross, (iii) Modified Casson, and (iv) Quemada. We have presented the numerical results in terms of wall shear stress (WSS), pressure distribution as well as the streamlines and discussed the hemodynamic behaviors for laminar and laminar to turbulent transitional flow conditions. An increase of wall shear stress and a decrease in wall pressure are significantly observed at the stenosis throat for high Reynolds number and highly stenosed arteries. Likewise, the flow recirculation also increases if the narrowing level and the Reynolds number increases in the dilated region which eventually leads the stream to experience a transition to turbulence at Re = 750. The results for the fluid flow through an aneurysm just after a stenosis with oscillating wall are novel in the literature.

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Numerical analysis of pulsatile blood flow and vessel wall mechanics in different degrees of stenoses

Cited by 136 publications

References 32 publications

Clinical important hemodynamic characteristics for serial stenosed coronary artery

Clinical important hemodynamic characteristics for serial stenosed coronary artery

An asymptotic method for the prediction of the anisotropic effective elastic properties of the cortical vein: superior sagittal sinus junction embedded within a homogenized cell element

Pulsatile Non-Newtonian Fluid Flows in a Model Aneurysm with Oscillating Wall

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