Numerical analysis of mechanical ventilation using high concentration medical gas mixtures in newborns

Katz, Ira; Milet, Aude; Chalopin, Matthieu; Farjot, Géraldine

doi:10.4103/2045-9912.273959

Cited by 4 publications

(4 citation statements)

References 42 publications

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“…We note that in a numerical analysis of argon mixtures and air in human newborns, the property value differences caused relatively minor differences in ventilation parameters during pressure controlled ventilation. 10 …”

Section: Aterials and M Ethodsmentioning

confidence: 99%

Argon pharmacokinetics: measurements in pigs and analysis in humans using a physiologically based pharmacokinetics model

Katz,

Tissier,

Kohlhauer

et al. 2024

Medical Gas Research

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The primary objective of this study was to investigate the pharmacokinetics of inhaled argon in young pigs using mechanical ventilation. Also a physiologically based model of argon pharmacokinetics (PBPK) is validated with human data for xenon from the literature and the new data from juvenile pigs. The inherent difficulty in performing pharmacokinetics studies of argon makes the use of the PBPK model especially relevant. The model is used to investigate argon pharmacokinetics for adult and neonate applications. Juvenile pigs (n = 4) were anesthetized, submitted to endotracheal intubation, and mechanical ventilation using a conventional ventilator. Argon inhalation was achieved by switching the animal from the first mechanical ventilator (with air/oxygen) to a second one that was supplied with 75% argon and 25% oxygen from premixed gas cylinders. This administration yielded blood samples that were analyzed using a quadrupole based technique for determining argon concentration. The range of blood:gas partition coefficient corresponding to the average measured Cmax of 190–872 μM is 0.005–0.022. Based on the average curve, T1/2= 75 seconds. The PBPK is shown to be in general agreement with the experimental data in pigs. Inhaled argon administration exhibited an on-off nature such that AUC was proportional to administration time. Confidence in the PBPK model and the remarkably robust and stable on-off nature of argon pharmacokinetics, notwithstanding intersubject variability and comorbidity, suggests that inhaled argon could readily be applied to any treatment regime.

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Section: Aterials and M Ethodsmentioning

confidence: 99%

Argon pharmacokinetics: measurements in pigs and analysis in humans using a physiologically based pharmacokinetics model

Katz,

Tissier,

Kohlhauer

et al. 2024

Medical Gas Research

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“…Argon mixtures with oxygen for therapeutic use are moderately more dense and viscous than air such that respiratory parameters during ventilation are similar to air. 9 However, this does not preclude the need for devices that are specifically calibrated for argon mixtures. Ventilation with Ar has been shown to be safe both in animals and in humans.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Therefore, compared to xenon, Ar would have low cost and production constraints allowing for large medical usage. Argon mixtures with oxygen for therapeutic use are moderately more dense and viscous than air such that respiratory parameters during ventilation are similar to air . However, this does not preclude the need for devices that are specifically calibrated for argon mixtures.…”

Section: Introductionmentioning

confidence: 99%

Method for the Identification of Potentially Bioactive Argon Binding Sites in Protein Families

Hammami

Farjot

Naveau

et al. 2022

J. Chem. Inf. Model.

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Argon belongs to the group of chemically inert noble gases, which display a remarkable spectrum of clinically useful biological properties. In an attempt to better understand noble gases, notably argon's mechanism of action, we mined a massive noble gas modelling database which lists all possible noble gas binding sites in the proteins from the Protein Data Bank. We developed a method of analysis to identify amongst all predicted noble gas binding sites, the potentially relevant ones within protein families which are likely to be modulated by Ar. Our method consists in determining within structurally aligned proteins, the conserved binding sites whose shape, localization, hydrophobicity and binding energies are to be further examined. This method was applied to the analysis of two protein families where crystallographic noble gas binding sites have been experimentally determined. Our findings indicate that amongst the most conserved binding sites, either the most hydrophobic one and/or the site which has the best binding energy correspond to the crystallographic noble gas binding sites with the best occupancies, therefore the best affinity for the gas. This method will allow us to predict relevant noble gas binding sites that have potential pharmacological interest and thus potential Ar targets that will be prioritized for further studies including in vitro validation.

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“…Other scientists used numerical tools to investigate airflow in the human trachea at different conditions [13,14]. Mechanical ventilation (MV) has also been a recent topic of research by some investigators [15][16][17][18][19][20] in attempts to quantify the impact of different MV modes on the aerodynamics of the airways in specific patients. Kingma et al, 2017 [21] conducted a recent comparison of four methods of endotracheal tube passage in simulated airways.…”

Section: Introductionmentioning

confidence: 99%

Endotracheal Tubes Design: The Role of Tube Bending

Dbouk

Drikakis

2021

Symmetry

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Endotracheal tubes (ETT) passed inside the human trachea witness tube bending at different angles, affecting the ocal fluid flow dynamics. This induces a variable mechanical ventilation performance across patients’ comfortability evels. Our understanding of the ocal fluid flow dynamics phenomena is thus crucial to enhance the maneuverability of ETT under operation. For the first time to our knowledge, we shed ight on ETT through computational fluid dynamics (CFD) to investigate the bending effect of ETT on the ocal airflow in volume-controlled mechanical ventilation. We considered an ETT with 180° arc bend configuration, including Murphy’s eye. We identified several flow phenomena associated with the bending, such as flow asymmetries, secondary flows, and vortex dynamics throughout the tube.

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Numerical analysis of mechanical ventilation using high concentration medical gas mixtures in newborns

Cited by 4 publications

References 42 publications

Argon pharmacokinetics: measurements in pigs and analysis in humans using a physiologically based pharmacokinetics model

Argon pharmacokinetics: measurements in pigs and analysis in humans using a physiologically based pharmacokinetics model

Method for the Identification of Potentially Bioactive Argon Binding Sites in Protein Families

Endotracheal Tubes Design: The Role of Tube Bending

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