Numerical Analysis of Drug Diffusion in Human Dermal Region with Linear Shape Function

Gupta, Vineeta Gupta Vineeta

doi:10.9790/5728-0423136

Cited by 4 publications

(1 citation statement)

References 9 publications

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“…Many workers (10, 20,22,23,37,38,39,40,41,42,43,44,45,46,47) have also Pseudomonas aeruginosa is the second predominant organism (25%) followed by Escherichia Coli 6%, Proteus 4% in the present study. On the contrary Pseudomonas was isolated as predominant agent by Gulati et al, (14) Kulkarni et al, (46) Gupta et al, (43) Fliss et al, (49) Kenne et al, (27) Taneja et al, (28) and Brooke et al (50) Pseudomonas aeruginosa and Proteus infection were considered mostly as secondary infection from the external canal entering the middle ear via perforated tympanic membrane. (51,52) Escherichia coli, Proteus, Enterococcus, and Klebsiella were the next commonly isolated organism in our study.…”

Section: Discussionmentioning

confidence: 99%

Bacteriological profile and antibiotic sensitivity in Chronic Suppurative Otitis Media

2016

IJASHNB

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Chronic Suppurative Otitis Media is a chronic inflammation of middle ear presents with recurrent otorrhoea through a tympanic perforation, usually occurs after upper respiratory viral infections followed by invasion of pyogenic organisms. Our prospective study, conducted over a period of 10 months, includes ear discharge from 100 patients with chronic suppurative ottis media. Discharge collected in sterile swabs were sent immediately to microbiology laboratory and processed. Bacterial isolates were identified by standard methods and antibiotic susceptibility testing was done. Staphylococcus was the predominant organism followed by Pseudomonas sps., and Escherichia Coli. Most of the organisms were sensitive to Cefotaxime followed by Amikacin. The aim of the study on aerobic microbes and their anti-biogram pattern was to prepare a protocol for empirical antibiotic therapy based on the study to shorten the period of infection.

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Section: Discussionmentioning

confidence: 99%

Bacteriological profile and antibiotic sensitivity in Chronic Suppurative Otitis Media

2016

IJASHNB

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Finite element analysis of non‐Newtonian magnetohemodynamic flow conveying nanoparticles through a stenosed coronary artery

Vasu

Dubey

Bég

2019

Heat Trans. Asian Res.

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The present study considers two-dimensional mathematical modeling of non-Newtonian nanofluid hemodynamics with heat and mass transfer in a stenosed coronary artery in the presence of a radial magnetic field. The second-grade differential viscoelastic constitutive model is adopted for blood to mimic non-Newtonian characteristics, and blood is considered to contain a homogenous suspension of nanoparticles. The Vogel model is employed to simulate the variation of blood viscosity as a function of temperature.The governing equations are an extension of the Navier-Stokes equations with linear Boussinesq's approximation and Buongiorno's nanoscale model (which simulates both heat and mass transfer). The conservation equations are normalized by employing appropriate nondimensional variables. It is assumed that the maximum height of the stenosis is small in comparison with the radius of the artery, and, furthermore, that the radius of the artery and length of the stenotic region are of comparable magnitude. To study the influence of vessel geometry on blood flow and nanoparticle transport, variation in the design and size of the stenosis is considered in the domain. The transformed equations are solved numerically by means of the finite element method based on the variational approach and simulated using the FreeFEM++ code. A detailed grid-independence study is included. Blood flow, heat, and mass transfer characteristics are examined for the effects of selected geometric, nanoscale, rheological, viscosity, and magnetic parameters, that is, stenotic diameter (d), viscoelastic parameter (λ 1 ), thermophoresis parameter (N t ), Brownian motion parameter (N b ), and magnetic body force parameter (M) at the throat of the stenosis and throughout the arterial domain. The velocity, temperature, and nanoparticle concentration fields are also visualized through instantaneous patterns of contours. An increase in magnetic and thermophoresis parameters is found to enhance the temperature, nanoparticle concentration, and skin-friction coefficient. Increasing Brownian motion parameter is observed to accelerate the blood flow. Narrower stenosis significantly alters the temperature and nanoparticle distributions and magnitudes. The novelty of the study relates to the combination of geometric complexity, multiphysical nanoscale, and thermomagnetic behavior, and also the simultaneous presence of biorheological behavior (all of which arise in actual cardiovascular heat transfer phenomena) in a single work with extensive visualization of the flow, heat, and mass transfer characteristics. The simulations are relevant to the diffusion of nano-drugs in magnettargeted treatment of stenosed arterial disease. K E Y W O R D Sarterial stenosis, finite element method, magnetohydrodynamics, nano-drugs, non-Newtonian blood flow, thermophoresis, Vogel's model

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Variational finite element method to study the absorption rate of drug at various compartments through transdermal drug delivery system

Khanday

Rafiq

2015

Alexandria Journal of Medicine

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Numerical Analysis of Drug Diffusion in Human Dermal Region with Linear Shape Function

Abstract: The present

Cited by 4 publications

References 9 publications

Bacteriological profile and antibiotic sensitivity in Chronic Suppurative Otitis Media

Bacteriological profile and antibiotic sensitivity in Chronic Suppurative Otitis Media

Finite element analysis of non‐Newtonian magnetohemodynamic flow conveying nanoparticles through a stenosed coronary artery

Variational finite element method to study the absorption rate of drug at various compartments through transdermal drug delivery system

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